LONGEVITY AMONG ETHNIC GROUPS IN ALCOHOLIC LIVER DISEASE |
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| Authors: | MENDENHALL CHARLES L; GARTSIDE PETER S; ROSELLE GARY A; GROSSMAN CHARLES J; WEESNER ROBERT E; CHEDIDH ANTONIO; VA Cooperative Study Group |
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| Institution: | *Veterans Administration Medical Center, Cincinnati, OH; University of Cincinnati Medical Center Cincinnati, OH
 Departments of Medicine, University of Health Sciences, Chicago Medical School Cincinnati, OH, U.S.A.
 Departments of Biostatistics University of Health Sciences, Chicago Medical School Cincinnati, OH, U.S.A.
 Departments of Physiology, University of Health Sciences, Chicago Medical School Xavier University Cincinnati, OH, U.S.A.
¶Departments of Pathology Xavier University Cincinnati, OH, U.S.A.
 Biology, Xavier University Cincinnati, OH, U.S.A. |
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| Abstract: | As part of a multicenter V.A. Cooperative Study, 437 male veteranswith varying stages of alcoholic liver injury were followedover a 4.5 year period. Their ethnic distribution consistedof 256 Caucasians, 109 black Afro-Americans, 63 Puerto RicanHispanics, and 9 Native American Indians. Survival analysesrevealed significant differences between groups (P = 0.0002):66% of Afro-Americans were still living at 42 months; Caucasianswere intermediate with 40% survival; and only 28% of Hispanicswere alive. The number of Native American Indians enrolled wastoo small to draw conclusions but none of those enrolled survivedbeyond 24 months. Survival regression analysis of 30 clinical,laboratory, histologic and nutritional parameters, revealedthe following significant risk factors: clinical severity (P< 0.0001), histologic severity (P < 0.0001), race (P =0.001), age (P = 0.002), BUN (P = 0.01) and ALT (P = 0.02).These analyses indicated that ethnicity, independent of othervariables, is significantly associated with outcome from thedisease. |
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