| 巨核细胞白血病发生与细胞因子网络失衡相关性研究 |
| |
| 引用本文： | 赵东长,杨默. 巨核细胞白血病发生与细胞因子网络失衡相关性研究[J]. 肿瘤防治研究, 2004, 31(6): 354-355,376 |
| |
| 作者姓名： | 赵东长 杨默 |
| |
| 作者单位： | 1. 510010广州,广东省妇幼保健院
2. 香港中文大学儿科学系 |
| |
| 摘 要： | 目的 了解巨核细胞白血病细胞因子的表达谱系。方法 用RT PCR方法结合Southern印迹检测 4个分化程度不同的巨核细胞株Meg 0 1、Dami、CHRF 2 88 11、与M 0 7e的多个细胞因子表达情况 ,并比较它们之间的差异性。结果 4个巨核细胞白血病细胞株均表达自分泌生长因子IL 1β、IL 3、IL 6 ,涉及免疫炎症反应的细胞因子IL 1α、IL 5和IL 12 p4 0仅在细胞分化程度高的Meg 0 1中表达 ,而且 4个巨核细胞株也存在不同的细胞因子表达谱系。结论 巨核细胞白血病的发生与细胞因子网络的失衡可能具有密切的关联性 ,值得今后在巨核细胞白血病病人的临床诊疗过程中进一步关注
|
| 关 键 词： | 巨核细胞 白血病 细胞因子 |
| 文章编号： | 1000-8578(2004)06-0354-02 |
| 收稿时间： | 2004-02-17 |
| 修稿时间： | 2004-04-14 |
Relationship between Megakaryocytic leukemogenesis and the Abnormalities of Cytokine Expression |
| |
| ZHAO Dong chang ,YANG Mo .Guangdong Province Maternal and Children's Hospital,Guangzhou ,China. Relationship between Megakaryocytic leukemogenesis and the Abnormalities of Cytokine Expression[J]. Cancer Research on Prevention and Treatment, 2004, 31(6): 354-355,376 |
| |
| Authors: | ZHAO Dong chang YANG Mo .Guangdong Province Maternal Children's Hospital Guangzhou China |
| |
| Affiliation: | ZHAO Dong chang 1,YANG Mo 21.Guangdong Province Maternal and Children's Hospital,Guangzhou 510010,China, 2.Department of Pediatrics,The Chinese University of Hong Kong |
| |
| Abstract: | Objective To study the expression of cytokine pattern in megakaryoblastic leukemic cells and the possible involvement of cytokines in megakaryoblastic leukemogesis.Methods RT PCR and Southern blot were used to detect cytokine mRNA expression in four megakaryoblastic cell lines: Meg 01, Dami, CHRF 288 11 and M 07e and also compare the differences of cytokine expression.Results Cytokine IL 1β, IL 3, and IL 6 were universally expressed in all of four megakaryoblastic cell lines. These cytokines may ... |
| |
| Keywords: | Megakaryocyte Leukemia Cytokine |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
| 点击此处可从《肿瘤防治研究》浏览原始摘要信息 |
|
点击此处可从《肿瘤防治研究》下载免费的PDF全文 |
