丹参川芎嗪对不稳定型心绞痛患者血脂影响及临床疗效

目的观察丹参川芎嗪注射液对冠心病不稳定型心绞痛患者血脂的影响及治疗不稳定型心绞痛的临床疗效。方法选取140例冠心病不稳定型心绞痛患者为研究对象,分为对照组70例和观察组70例。对照组给予常规治疗,观察组在常规治疗基础上给予加丹参川芎嗪注射液10 mL,1次/d,静脉滴注,疗程14d。结果 （1）观察组TC、TG、LDL-C较治疗前下降（P〈0.05）;HDL-C较治疗前升高（P〈0.05）。对照组TC、LDL-C较治疗前下降（P〈0.05）;HDL-C升高（P〈0.05）;TG略有下降,但差异无统计学意义（P〉0.05）,两组结果对比差异有统计学意义（P〈0.05）。（2）治疗后两组心绞痛发作频率、每次发作持续时间、心电图ST段改变较治疗前均有改善,观察组组内比较结果示P〈0.01,对照组组内比较P〈0.05。,两组结果对比,差异有统计学意义（P〈0.05）;临床总有效率观察组高于对照组（P〈0.05）。结论丹参川芎嗪注射液对不稳定型心绞痛患者有降脂作用,并进一步缓解临床症状,改善心肌缺血,减少心绞痛的发生,优于单独常规治疗。

Effect of Danshenchuanqiongqin on bloodLipids in patients with unstableangina and treating unstableanginapectoris

【Objective】 To investigate the effect of Danshen chuanqiongqin on BloodLipids in patients with unstableAngina and treating unstableanginapectoris.【Methods】 140 cases with unstableangina were randomly divided into Controlgrouptreatmentgroup（n=70,,routinetreatmentonly）andtreatment group（n=70,routine treatment added Danshen chuanqingqin 10ml qdivgtt for 2 weeks）.【Results】（1）After 2 weeks the level of TC,TG,LDL-C in control group dropped to lower level（P0.05）,the level of HDL-C increased in control group（P0.05）,the level of TG dropped to low level in control group（P0.05）.The result of the treatment group is higher than control group（P0.05）.（2） Compared with control group the anginapectoris and electrocardiogram（ECG） abnormal change of treatment group significantly decreased（P0.05） and the treatment group decreased significantly rather than the control group（P0.05）.【Conclusion】 Danshenchuanqiongqin possesses effect on treating unstableanginapectoris and on Blood Lipids in patients with unstableangina.