Fracture prevention with vitamin D supplementation: considering the inconsistent results |
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| Authors: | Gerbrand J Izaks |
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| Affiliation: | (1) Department of General Internal Medicine and Geriatrics, University Medical Centre Groningen, P.O. Box 30.001, 9700, RB, Groningen, The Netherlands |
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| Abstract: | Background A meta-analysis found that high dose vitamin D, different from low dose, decreased fracture risk by 23% for any nonvertebral fracture and by 26% for hip fracture. Unfortunately, however, this effect was not confirmed by recent trials. The aim of this paper is to explore if this inconsistency can be attributed to publication bias or heterogeneity of the trials. |
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