HIV-1 drug resistance in HIV-1-infected children in the United Kingdom from 1998 to 2004 |
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| Authors: | Chakraborty Rana,Smith Colette J,Dunn David,Green Hannah,Duong Trinh,Doerholt Katja,Riordon Andrew,Lyall Hermione,Tookey Pat,Butler Karina,Sabin Caroline A,Gibb Di,Pillay Deenan Collaborative HIV Paediatric Study UK Collaborative Group on HIV Drug Resistance |
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| Affiliation: | Paediatric Infectious Diseases Unit, St. George's Hospital, London. rchakrab@sgul.ac.uk |
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| Abstract: | We reviewed HIV-1 genotypes from 200 of 979 (20%) HIV-infected children in the U.K. Collaborative HIV in Pediatric Study (CHIPS) cohort (343 resistance tests). Three of 44 samples had major primary resistance mutations before antiretroviral therapy. Three-class resistance was noted in 42 samples (14.1%). Our study also highlighted underutilization of testing and the need for prompt genotyping after drug discontinuation which may have lead to an underestimation of HIV-1 resistance. |
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