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Differential mechanism of retention of Cu-pyruvaldehyde-bis(N4-methylthiosemicarbazone) (Cu-PTSM) by brain and tumor: A novel radiopharmaceutical for positron emission tomography imaging |
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| Authors: | Yasuhisa Fujibayashi Hideyuki Taniuchi Kouichi Wada Yoshiharu Yonekura Junji Konishi Akira Yokoyama |
| Affiliation: | 1. Department of Genetic Biochemistry, Faculty of Pharmaceutical Sciences, Kyoto University, Japan 2. Department of Radiopharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Kyoto University, Yoshida, Sakyo-ku, 606, Kyoto, Japan 3. Department of Brain Pathophysiology, Kyoto University Hospital, Japan 4. Department of Nuclear Medicine, Kyoto University Hospital, Japan |
| Abstract: | The reductive retention of62Cu-PTSM was comparatively studied in the brain and Ehrlich ascites tumor cells by electron spin resonance spectrometry and nonradioactive Cu-PTSM. In the brain, only the mitochondrial fraction showed the ability to reduce Cu-PTSM, and the other subcellular fractions did not. In contrast, the cytosolic fraction of Ehrlich ascites tumor cells was the specific site of Cu-PTSM reduction. It was therefore considered that the retention of Cu-PTSM in the brain is closely related to mitochondrial reduction, most probably involving the mitochondrial electron transport system. |
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