| 食管鳞癌特殊亚型的免疫组化表型及其增殖活性的研究 |
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| 引用本文： | 黄晓赤 罗克枢 等. 食管鳞癌特殊亚型的免疫组化表型及其增殖活性的研究[J]. 四川肿瘤防治, 2002, 15(1): 4-6 |
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| 作者姓名： | 黄晓赤 罗克枢 等 |
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| 作者单位： | [1]成都市第六人民医院病理科，成都610051 [2]成都军区总医院病理科，成都610083 |
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| 摘 要： | 目的：探讨食管鳞癌特殊亚型的免疫组化表型和细胞增殖活性。方法：用免疫组化S－P法检测鳞癌4种亚型的免疫组化表型、PCNA和p53蛋白。结果：（1）这些亚型的免疫组化表型与其形态分化有关；（2）PCNA和p53蛋白在梭形细胞鳞癌（SCSC）和基底细胞样鳞癌（BSC）中表达更为显著。结论：在食管鳞癌特殊亚型中，SCSC和BSC型，尤其是后者具有低分化高增殖活性以及明显的临床侵袭行为。
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| 关 键 词： | 食管鳞癌 免疫组织化学 增殖活性 |
| 文章编号： | 1007-0281(2002)01-0004-03 |
| 修稿时间： | 2001-11-07 |
The Special Subtypes of Esophagus Squamous Carcinoma:A Study of Immunohistochemical Phenotype and Cell Proliferative Activity |
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| HUANG Xiao-chi,ZHAO Jian-pin,LOU Ke-shu,et al.. The Special Subtypes of Esophagus Squamous Carcinoma:A Study of Immunohistochemical Phenotype and Cell Proliferative Activity[J]. Sichuan Journal of Cancer Control, 2002, 15(1): 4-6 |
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| Authors: | HUANG Xiao-chi ZHAO Jian-pin LOU Ke-shu et al. |
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| Affiliation: | HUANG Xiao-chi,ZHAO Jian-pin,LOU Ke-shu,et al.Dept of Pathol,Sixth People's Hospital of Chengdu,Chengdu 610051 |
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| Abstract: | Objective: To study the characters of immunohistochemical phenotype and cell proliferative activity in special subtypes of the esophagus squamous carcinoma.Methods:Immunohistochemical phenotype,PCNA and p53 protein of four subtypes of squamous carcinoma were marked by immunohistochmical S-P method.Results:(1)The immunohistochemical phenotypes of these subtypes is relative to their morphological differentiation; (2)The expression of PCNA and p53 protien was more prominent in SCSC and BSC than in ASC and SrCSC.Conclusion:Of the special subtypes of esophagus squamous carcinoma SCSC and BSC ,in especial latter,have a poor diffrentiation, high proliferation activity and evident clinical aggressive behavior. |
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| Keywords: | Esophagus Squamous carcinoma Immunohistochemistry Proliferative activity |
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