|
|||||
|
|
| 纳洛酮对缺血再灌注心肌c-fos基因表达的影响 | |
| 引用本文： | 张赤,万红,万德宁,王焱林.纳洛酮对缺血再灌注心肌c-fos基因表达的影响[J].临床麻醉学杂志,2000,16(10):506-507. |
| 作者姓名： | 张赤 万红 万德宁 王焱林 |
| 作者单位： | 1. 深圳市东湖医院麻醉科,518020 2. 湖北医科大学附一院麻醉科 3. 湖北医科大学附二院麻醉科 |
| 摘 要： | 目的：研究纳洛酮对心肌缺血再灌注损伤的影响，从分子水平探讨心肌缺血再灌注损伤的保护机制。方法：３０只大白兔分为三组：（１）对照组；（２）心肌缺血３０分钟再灌３０分钟组；（３）静注纳洛酮１０分钟后缺血３０分钟再灌３０分钟组。提取心肌总ＰＮＡ与经同位素标记的ｃ－ｆｏｓ ｃＤＮＡ探针进行分子杂交并自显影，测定ｃ－ｆｏｓ基因ｍＲ－ＮＡ水平。结果：纳洛酮能显著抑制心肌缺血再灌注时ｃ－ｆｏｓ基因的表达。结论： |
| 关 键 词： | 心肌缺血 c－fos基因 纳洛酮 再灌注损伤 |
Effects of Naloxone on Expression of c-fos Gene during Global Myocardial Ischemia-reperfusion |
|
| Zhang Chi,Wan Hong,Wan Dening,et al.Effects of Naloxone on Expression of c-fos Gene during Global Myocardial Ischemia-reperfusion[J].The Journal of Clinical Anesthesiology,2000,16(10):506-507. | |
| Authors: | Zhang Chi Wan Hong Wan Dening et al |
| Institution: | Zhang Chi,Wan Hong,Wan Dening,et al Department of Anesthesiology,Shenzhen East Lake Hospital,Shenzhen 518020 |
| Abstract: | Objective:To observe the effects of naloxone on expression of c fos gene during global myocardial ischemia reperfusion.Methods:30 rabbits were randomly divided into control group,IR group(ischemic 30min reperfusion 30min) and NAL group (naloxone was injected before IR).Total cellular RNA was isolated after 30min of ischemia and reperfusion.Optical density(OD) value was measured.Results:OD values decreased more in NAL group than that in IR group.Conclusion:Naloxone depresses effectively the expression of c fos gene.In the molecular modulation,naloxone may protect myocardium from ischemia reperfusion injury. |
| Keywords: | Myocardial protection Ischemia reperfusion injury c fos gene Nalox4 |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |