部分植物提取物及药物对中波紫外线诱导的色素沉着斑的抑制作用

目的:检测植物提取物对皮肤色素沉着的抑制作用.方法:以窄谱中波紫外线(NB-UVB)1.5倍的最小红斑量照射,在受试者腹部皮肤建立人工色素沉着模型,分别用3%和5%烟酰胺、1%美白因子、1%羽扇豆素、1%沙棘油、1%和3%橙皮苷、3%维生素C磷酸酯镁、3%甘草酸二铵乳膏涂抹在模型各区域内,以3%氢醌霜为阳性对照,基质为阴性对照,未用药组作空白对照.分别在照射前、照射后1周(即用药前)、用药后第1、2、4、6、8周进行皮肤颜色测量.结果:紫外线照射后7周内,局部皮肤血红蛋白逐渐减少、胶原蛋白合成增加,表皮黑素总量增加.与空白对照区域和阴性对照区域相比,应用1%羽扇豆素、1%沙棘油、3%橙皮苷、3%烟酰胺等制剂的区域,L*值显著增加,高于(P<0.05)或近似于3%氢醌组(P>0.05);局部血红蛋白含量<氢醌组(P<0.01),与基质组相似(P>0.05);且对局部胶原蛋白的合成有轻度促进作用;用SIAscopy<'TM>测定出的局部黑素总量也显著小于空白对照组和阴性对照组(P<0.01),与氢醌组比较差异无统计学意义(P>0.05).结论:羽扇豆素、沙棘油、橙皮苷、烟酰胺、维生素C磷酸酯镁、甘草酸二铵、美白因子使紫外线照射后的色素沉着减轻,作用与氢醌相当,且刺激性小.

Effects of some plant extracts on the pigmentation induced by UVB

Objective:To detect the inhibitory action of the extracts from some plants on skin pigmentation.Methods:Pig-mentary macules were induced by irradiating the abdominal regions with 1.5 folds of MED of narrowband-UVB light.Various whitening agents,including 3% and 5% nicotinamide creams,1% whitening factor,1% albu-lupin,1% buckthorn oil,1% and 3% hesperidin,3% magnesium ascorbyl phosphate,3% diammonium glycyrrhizinate creams were applied to the irradiated ar-eas.Before and a week after the irradiation,and one,...