异丙酚对猕猴再灌注肺损伤的保护作用机制

目的 通过观察异丙酚在猕猴失血性休克并复苏过程中对病理生理学变化的作用,探讨休克复苏引起肺损伤的原因和异丙酚的保护作用机制.方法 12只猕猴按随机数字表法分为对照组和异丙酚组,每组6只.建立失血性休克复苏导致再灌注肺损伤的动物模型.异丙酚组猕猴除在放血前用计算机靶控技术输注异丙酚使猴血浆异丙酚浓度达到8 mg/L并维持此水平到实验结束外,其余操作与对照组相同.分别于放血前、休克2 h和复苏2 h测定血流动力学参数,并抽动脉血行血气分析、血常规检验.结果 异丙酚组在休克2 h和复苏2 h时平均肺动脉压(MPA)、肺血管阻力指数(PVRI)均明显低于对照组(P＜0.05),血小板(PLT)计数明显高于对照组(P＜0.01);复苏2 h时异丙酚组白细胞(WBC)计数明显低于对照组(P＜0.01).结论 休克复苏时肺动脉高压和全身炎性反应可能是导致肺损伤的原因,异丙酚可通过降低肺动脉压和减轻全身炎性反应显著减轻肺损伤.

Propofol protects Rhesus macaques from reperfusion lung injury

Objective To find out the cause of lung injury due to hemorrhagic shock and resuscitation, and the mechanism of propofol protecting Rhesus macaques from lung injury. Methods Twelve healthy Rhesus macaques were randomly divided into two groups: propofol group and control group. The animal model was made by 2-hour hemorrhagic shock and 2-hour resuscitation. Rhesus macaques in propofol group were given propofol at a plasma concentration of 8 mg/L all through by the technique of target controlled infusion. Hemo...