| 粉红粘帚霉1A毒杀线虫活性代谢物的研究 |
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| 引用本文： | 董锦艳,李铷,周艳,张克勤. 粉红粘帚霉1A毒杀线虫活性代谢物的研究[J]. 中国抗生素杂志, 2006, 31(4): 232-236 |
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| 作者姓名： | 董锦艳 李铷 周艳 张克勤 |
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| 作者单位： | 云南省生物资源保护与利用重点实验室,云南大学,昆明,650091 |
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| 基金项目： | 云南省科技厅资助项目;中国科学院资助项目 |
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| 摘 要： | 在研究粉红粘帚霉Gliocladium roseum 1A抗线虫活性代谢产物的过程中，活性跟踪分离获得4个化合物。通过UV、IR、MS、^1H-NMR,^13C-NMR、DEPT、^1H-1H COSY、HMQC、HMBC等波谱分析，鉴定其结构分别与轮枝菌素A、11’-脱氧轮枝菌素、sch52900和sch52901相同。首次报道这4个化合物对线虫的毒杀活性。
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| 关 键 词： | 线虫 粉红粘帚霉 轮枝菌素A 11'-脱氧轮枝菌素A |
| 文章编号： | 1001-8689(2006)04-0232-05 |
| 收稿时间： | 2005-07-06 |
| 修稿时间： | 2005-10-25 |
Four nematocidal metabolites of Gliocladium roseum 1A |
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| Dong Jin-yan,Li Ru,Zhou Yan,Zhang Ke-qin. Four nematocidal metabolites of Gliocladium roseum 1A[J]. Chinese Journal of Antibiotics, 2006, 31(4): 232-236 |
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| Authors: | Dong Jin-yan Li Ru Zhou Yan Zhang Ke-qin |
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| Affiliation: | Key Laboratory for Conservation and Utilization of Bioresources, Yunnan University, Kunming 650091 |
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| Abstract: | During the course of investigation of the antinematodal metabolites against Caenorhabditis elegans and Panagrellus redivivus from wheat solid-culture of Gliocladium roseum 1A,four antibiotics that exhibited the nematocidal activity to both tested nematodes were isolated.By spectral(UV,IR,MS,1H-NMR,13C-NMR,DEPT,1H-1H COSY,HMQC,HMBC) analysis,their structures were identified as verticillin A,11'-deoxyverticillin A,sch52900,and sch52901.The nematocidal activities of four compounds were reported for the first time. |
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| Keywords: | sch52900 sch52901 |
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