雾化吸入肺表面活性物质治疗新生儿胎粪吸入综合征

目的 探讨雾化吸入肺表面活性物质（pulmonary surfactant,PS)治疗新生儿胎粪吸入综合征（meconium aspairation syndrome,MAS)的有效性及临床价值。方法 采用雾化吸入PS治疗12例MAS患儿，其中8例接受PS2次，2例接受PS3次。结果 给予首剂PS15min后患儿青紫迅速消失，皮肤转红润，经皮测定血氧饱和度（TcSaO2)升高，30min后患儿低氧血症迅速改善，动脉血氧分压（PaO2)，动脉血氧分压和吸入氧浓度比值（PaO2/FiO2)，动脉肺泡血氧分压比值（a/APO2)较治疗前显著增高（P＜0．05），重复应用PS后亦有相似的疗效。结论 PS能有效地改善MAS患儿肺顺应性及氧合功能，重复应用PS可巩固和加强疗效。

Clinical Study of nebulizing pulmonary surfactant therapy in neonates with meconium aspiration syndrome

Objective To study the efficacy and values of nebulizing pulmonary surfactant therapy in neonates with meconium aspiration syndrome (MAS). Methods Twelve neonates with MAS were received nebulizing pulmonary surfactant therapy.Eight of them received a second dose of surfactant and two received a third dose. Results Hypoxemia in the patients was markedly improvement after the first dose of surfactant administration, Values for arterial partial pressure oxygen(PaO 2),PaO 2/fraction of inspired oxygen(FiO 2) ratio,arterial oxygen/alveolar oxygen(a/APO 2) ratio were significantly increase.Similar efficacy was seen after repeated administration of surfactant. Conclusion Pulmonary surfactant therapy may result in a rapid improvement in lung compliance and oxygenation in newborns with MAS.Similar efficacy was obtained after the second dose and third dose administration.