NK细胞受体与相关配体

NK细胞表面表达非抗原特异性的受体。按分子结构分类,NK细胞受体可分为Ig超家族和C型凝集素超家族。按其介导的功能,可分为NK细胞激活性受体(NKAR)与NK细胞抑制性受体(NKIR)。NKAR包括介导ADCC的CD16,介导自然杀伤的NKR-P1、与DAP12相偶联的KAR,以及协同刺激受体等。它们多依赖胞浆内ITAM模体传递激活信号。NKIR主要包括KIR与CD94/NKG2复合体,其特异性配体为MHC-I类分子,与NK细胞识别自体细胞密切相关。NKIR需要与NKAR共聚,借助胞浆内的ITIM模体来抑制激活性受体的活化及NK细胞的细胞毒作用。

NK cell receptors and related ligands

NK cell has antigen-non-specific receptors on its surface.Based on the mole cular structure,NK cell receptors can be divided into two types,including Ig superfamily and C-type lectin superfamily.Based on function,NK cell receptors can be divided into activation receptors(NKAR)and inhibition receptors(NKIR) .NKAR includes CD16mediating antibody dependent cytotoxicity,NKR-P1mediati ng natural cytotoxicity,KAR conjugated with DAP12and co-stimulatory receptor .They transduce signal through the ITAM motif in their cytoplasmic region.NKIR mainly include KIR and CD94/NKG2.Their ligands are MHC-I molecules.They ar e closely related to the recognition of auto cells by NK cells.Inhibition of NK AR activation and cytotoxic effect of NK cells by NKIR are carried out through the ITIM motif and require co-aggregation of NKAR and NKIR.