EFFECTS OF ENALAPRIL AND HYDROCHLOROTHIAZIDE ON BLOOD PRESSURE, RENIN–ANGIOTENSIN SYSTEM, AND ATRIAL NATRIURETIC FACTOR IN ESSENTIAL HYPERTENSION: A DOUBLE BLIND FACTORIAL CROSS-OVER STUDY |
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| Authors: | J. P. Chalmers L. M. H. Wing M. J. West A. J. C. Bune J. M. Elliott M. J. Morris M. D. Cain J. R. Graham D. O. Southgate |
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| Affiliation: | Professor of Medicine, Flinders Medical Centre, Adelaide;Associate Professor in Clinical Pharmacology, Flinders Medical Centre, Adelaide;Associate Professor of Medicine, Flinders Medical Centre, Adelaide;Senior Lecturer in Medicine, Repatriation General Hospital, Adelaide;Clinical Research Fellow in Hypertension Clinic, Flinders Medical Centre, Adelaide;Postdoctoral Fellow, Flinders Medical Centre, Adelaide;Principal Hospital Scientist, Flinders Medical Centre, Adelaide;Lecturer in Medicine, Flinders Medical Centre, Adelaide;Associate Professor in Primary Care and Community Medicine, Flinders Medical Centre, Adelaide |
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| Abstract: | The hypotensive and hormonal effects of the angiotensin converting enzyme (ACE) inhibitor enalapril (10 mg twice daily) were compared with those of hydrochlorothiazide (25 mg twice daily), with the two drugs in combination and with placebo in 21 patients with essential hypertension. For each patient there were four randomised double-blind treatment phases, each of four weeks' duration, which comprised a 2 times 2 factorial experiment. |
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| Keywords: | Angiotensin converting enzyme inhibitors enalapril thiazide diuretics blood pressure renin-angiotensin system atrial natriuretic factor |
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