N-methyl-d-aspartate and hypoxia induced Ca-changes in the CA1 region of the hippocampal slice |
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Authors: | David Ashton Kenneth Reid Roland Willems Albert Wauquier |
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Abstract: | Hypoxic neuronal depolarization was accompanied by a large decrease in extracellular [Ca2+]. After reoxygenation, the time at which [Ca2+] normalized was correlated with the extent of recovery of N-methyl-d-aspartate (NMDA) and synaptic responses. There was no evidence that the NMDA receptor system was more disrupted following hypoxia than the receptors involved in synaptic transmission. The Na+/K+ pump appeared to be better able to recover from hypoxia than the NMDA responses or synaptic transmission. |
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Keywords: | N-methyl-d-aspartate Hypoxia Calcium Hippocampal slice Excitatory amino acid |
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