| 云母对实验性胃溃疡愈合质量的影响 |
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| 引用本文： | 姒健敏,钱云,吴加国.云母对实验性胃溃疡愈合质量的影响[J].中国中药杂志,2005,30(19):1536-1541. |
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| 作者姓名： | 姒健敏 钱云 吴加国 |
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| 作者单位： | 浙江大学,邵逸夫临床医学研究所,浙江,杭州,310016 |
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| 摘 要： | 目的:探讨云母对实验性胃溃疡愈合质量的影响。方法:建立实验性醋酸致大鼠胃溃疡模型,成模后分组给药治疗14 d,取其标本,评估再生黏膜组织学及功能成熟度,以判定溃疡愈合质量。结果:经云母治疗后,大鼠再生黏膜厚度增加、囊状扩张腺体数目减少,肉芽组织炎症细胞浸润数量减少、微血管数量增加、胶原面积增加,黏膜中性黏液和氨基己糖分泌增多,血浆PGE2,EGF分泌增多,免疫组化染色中黏膜局部EGFR,bFGF阳性细胞表达增强。结论:云母能提高再生黏膜组织学及功能成熟度,最终达到高质量的溃疡愈合。
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| 关 键 词： | 云母 胃溃疡 溃疡愈合质量 |
| 文章编号： | 1001-5302（2005）19-1536-06 |
| 收稿时间： | 2004-12-14 |
| 修稿时间： | 2004-12-14 |
The effect of muscovite on the quality of gastric ulcer healing |
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| SI Jian-min;QIAN Yun;WU Jia-guo.The effect of muscovite on the quality of gastric ulcer healing[J].China Journal of Chinese Materia Medica,2005,30(19):1536-1541. |
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| Authors: | SI Jian-min;QIAN Yun;WU Jia-guo |
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| Institution: | Institue of Clinic Medicine Research of Sir Run Run Shaw, Zhejiang University, Hangzhou 310016, China |
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| Abstract: | Objective: To explore the effect of muscovite on the quality of gastric ulcer healing.Method: Gastric ulcers were produced in male rats by serosal application of acetic acid.Rats were gavaged for 14 days with saline,omeprazole and muscovite starting 3 days after ulcer induction.Then the tissue and blood samples were obtained and measured.Result: In the muscovite group,restored mucosa thickness increased,cystically dilated glands decreased,microvessels in connective tissue increased,the secretion of mucus,hexosamine, PGE2,EGF,bFGF were enhanced,and the express of EGFR was stronger. Conclusion: Muscovite can promote the gastric ulcer healing and improve the quality of gastric ulcer healing. |
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| Keywords: | muscovite gastric ulcer the quality of ulcer healing(QOUH) |
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