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Reversible contraception for women at high risk of fetal anomalies
Authors:D A Grimes
Affiliation:1. Yale Comprehensive Epilepsy Center, Department of Neurology, Yale School of Medicine, New Haven, CT, United States of America;2. Yale Cancer Center, New Haven, CT, United States of America;3. Second Faculty of Medicine, Medical University of Warsaw, Warsaw, Poland;4. Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT, United States of America;5. David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA, United States of America;1. Division of Gynecology, Department of Surgery, Boston Children''s Hospital, Boston, Massachusetts;2. Department of Obstetrics, Gynecology, and Reproductive Biology, Harvard Medical School, Boston, Massachusetts;3. Division of Endocrinology, Department of Pediatrics, Boston Children''s Hospital, Boston, Massachusetts;4. Department of Pediatrics, Harvard Medical School, Boston, Massachusetts;5. Division of Adolescent/Young Adult Medicine, Boston Children''s Hospital, Boston, Massachusetts;6. Channing Division of Network Medicine, Department of Medicine, Brigham and Women''s Hospital, Boston, Massachusetts;7. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts;8. Department of Plastic and Oral Surgery, Boston Children''s Hospital, Boston, Massachusetts;9. Center for Gender Surgery, Boston Children''s Hospital, Boston, Massachusetts
Abstract:Women at risk of pregnancy who are taking potentially teratogenic drugs need to use highly effective contraception. The choice of contraception should reflect the woman's feelings about induced abortion as a backup in case of contraceptive failure. If abortion is acceptable, use of any contraceptive seems reasonable. If abortion is not acceptable, depomedroxyprogesterone acetate, oral contraceptives, and intrauterine devices (each used with a condom) should provide the greatest protection against pregnancy. For most young women, the contraceptive of choice will be a low-dose oral contraceptive.
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