柳珊瑚酸对离体豚鼠气管的兴奋作用

柳珊瑚酸(suberogorgin,Sub)依浓度提高离体豚鼠气管张力,其ED50为52.5μmol·L^-1,比Gal和ACh弱。Sub对气管张力作用的剂量—效应曲线可因Atr0.13μmol·L^-1,CBT2.4μg·mL^-1或TTX1μmol·L^-1而右移或下移,最大效应降低。Atr0.65μmol·L^-1完全拮抗Sub的作用。在Gal35.5μmol·L^-1致挛的气管ACh使气管张力进一步提高而Sub不改变气管张力。

EXCITANT EFFECT OF SUBER OGORGIN ON ISOLATED GUINEA PIG TRACHEAWD

Suberogorgin(Sub) was shown to increase the tension of isolated guinea pigtrachea in a dose dependent manner. Its ED50 was 52.5μmol·L^-1. The stimulation of sub ontrachea was antagonized by atropine 0.65μmol·L^-1, and inhibited by atropine 0. 13μmol·L^-1,cobrotoxin2.4μg· mL^-1 and by tetrodotoxin lμmol·L^-1. On the contracted trachea induced bygalanthamine 35.5μmol·L^-1 , acetylcholine increased the tension but Sub dIu not. Galanthaminewas also shown not to increase the tension of trachea that had been treated with Sub 258μmol·L^-1for 10 min. The results indicate that the trachea-excitant action of Sub is related to the M and Nreceptor and the Na⁺ channel.