| 对曾氏推导的药物蛋白结合率公式的修正 |
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| 引用本文： | 娄建石.对曾氏推导的药物蛋白结合率公式的修正[J].药学学报,1994,29(11):872-873. |
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| 作者姓名： | 娄建石 |
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| 作者单位： | 天津医科大学药理教研室 |
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| 摘 要： | 对曾氏推导的药物蛋白结合率公式的修正娄建石（天津医科大学药理教研室，天津３０００７０）测定药物蛋白结合率是药物代谢动力学研究中的重要内容之一。曾衍霖教授根据国外文献推导出药物蛋白结合率公式（１），为这方面的研究提供了很好的计算依据。本文作者在计算药物...
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| 关 键 词： | 药物蛋白结合 |
| 收稿时间： | 1994-05-30 |
A MODIFICATION OF THE FORMULA OF DRUG PROTEINBIN BDING RATE DERlVED BY ZENG |
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| JSLou.A MODIFICATION OF THE FORMULA OF DRUG PROTEINBIN BDING RATE DERlVED BY ZENG[J].Acta Pharmaceutica Sinica,1994,29(11):872-873. |
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| Authors: | JSLou |
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| Abstract: | The formula of drug protein binding rate derived by Zeng is modified in this paper.According to the principle of equilibrium dialysis ,the modified formula of drug protein binding rate is as follows:where,W is the water of percentage(%)in plasma;,D]and PD] are the concentration(g/L)of protein ,free drug and protein-bound,respectively;βp is the apparent maxium binding capacity ofprotein(μmol/g);Kdp is the dissociation constant of drug-protein complex(μmol/L). |
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| Keywords: | Drug protein binding |
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