| 关附甲素抑制犬冠脉结扎引起的心律失常 |
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| 引用本文： | 王友群,苏玲,龚国清,刘静涵. 关附甲素抑制犬冠脉结扎引起的心律失常[J]. 药学学报, 1994, 29(2): 141-144 |
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| 作者姓名： | 王友群 苏玲 龚国清 刘静涵 |
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| 作者单位： | 南京中国药科大学药理研究室 |
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| 摘 要： | 关附甲素抑制犬冠脉结扎引起的心律失常王友群，苏玲，龚国清，刘静涵（南京中国药科大学药理研究室，中草药化学教研室２１０００９）关附甲素（ｇｕａｎｆｕｂａｓｅＡ，ＧＦＡ）是从关白附子中提取的一种二萜类生物碱（１，２）。现已发现它能抑制乌头碱、哇巴因和氯化...
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| 关 键 词： | 关附甲素 心肌梗塞 室性心律失常 抗心律失常药 |
| 收稿时间： | 1993-03-30 |
GUANFU BAsE A INHIBIT THE POST- INFARCTION VENTRICULAR ARRHYTHM IAS INDOGS |
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| YQ Wang,LSu,GQGong and JH Liu. GUANFU BAsE A INHIBIT THE POST- INFARCTION VENTRICULAR ARRHYTHM IAS INDOGS[J]. Acta pharmaceutica Sinica, 1994, 29(2): 141-144 |
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| Authors: | YQ Wang LSu GQGong JH Liu |
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| Abstract: | Harris tow- stage left anterior coronary ligation was performed in anesthetizeddogs.After twenty hours,severe ventricular arrhythmias were recorded under conscious state.Cumu-lative intravenous injections of guanfu base A,a new alkaloid isolated from the tuber of Aconitumcoreanum in China,from 1 0 to 4 0 mg· kg-1produced remarkable antiarrhythmic effect lasting over30 min and a moderate reduction of heart rate. The P-R interval,QRS complex and Q-Tinterval ofthe sinus rhythm were not significantly altered.The antiarrhythmic potency of guanfu base A in thismodel was found to be about one third that of quinidine. |
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| Keywords: | Guanfu base A Myocardial infarction Ventricular arrhythmias Antiarrhythmic agents |
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