| 促性腺激素释放多肽(GRP)对体外培养小鼠垂体分泌LH的影响 |
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| 引用本文： | 王乃功,关慕贞,王德心,鲁桂琛. 促性腺激素释放多肽(GRP)对体外培养小鼠垂体分泌LH的影响[J]. 药学学报, 1994, 29(8): 581-584 |
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| 作者姓名： | 王乃功 关慕贞 王德心 鲁桂琛 |
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| 作者单位： | 中国医学科学院，中国协和医科大学药物研究所 |
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| 摘 要： | 合成的促性腺激素释放多肽(GRP)及其类似物GRp～NH2,[Glu7.9.14Lys6.10]GRP(6～14),[phe14]GRP(5～14)和[phe14]GRP浓度在0.05mmol·L-1时,具有刺激体外培养的小鼠垂体分泌LH的作用。其活性依此相当对照垂体的115.4,114.2,140,160和179%。小鼠于妊振第7～9天或第1～5天,每只sc[phe14]GRP1mg·d-1,或于妊娠第2～4天每只sc[phe14]GRP(5～14)1mg·d-1,有40～60%的妊娠动物出现死胎。
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| 关 键 词： | 促性腺激素释放多肽 抗早孕 抗着床 促黄体生成激素(LH) |
| 收稿时间： | 1994-02-07 |
EFFECT OF GONADOTROPIN-RELEASING PEPTIDE (GRP) ON LH SECRETION OF MOUSE PITUITARY IN VITRO |
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| HG Wang,MZ Guan,DX Wang and GS Lu. EFFECT OF GONADOTROPIN-RELEASING PEPTIDE (GRP) ON LH SECRETION OF MOUSE PITUITARY IN VITRO[J]. Acta pharmaceutica Sinica, 1994, 29(8): 581-584 |
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| Authors: | HG Wang MZ Guan DX Wang GS Lu |
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| Abstract: | Synthetic GRP and its analogues ,GRP-NH2,[Glu7.9.14 Lys6.10] GRP(6～14),[Phe14]GRP(5～14)and[Phe14]GRP,at the concentration of 0.05 mmol·L-1 were shown tohave stimulatory effect on LH secretion in cultured mouse pituitary in vitro. The luteotropin releasingactivity of GRP and its analogues was estimated to be 115.4,114.2,140.0,162.0 and 179.0%ofthe control group,respectively. Subcutaneous administration of [Phe14]GRP on days 7～9 and 1～5 of pregnancy and [phe14]GRP(5～14)on days 2～4 of gestation at dosage of 1 mg·d-1(eachmouse)caused fetal death in 40～60% of mice. |
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| Keywords: | Gonadotropin-releasing peptide Interruption of early pregnancy Anti-implanta-tion LH |
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