| 群勃龙及其人尿代谢物的GC/MSD分析 |
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| 引用本文： | 叶荔,张长久,张亦中,刘欣. 群勃龙及其人尿代谢物的GC/MSD分析[J]. 药学学报, 1994, 29(1): 61-67 |
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| 作者姓名： | 叶荔 张长久 张亦中 刘欣 |
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| 作者单位： | 国家体委运动医学研究所 |
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| 摘 要： | 群勃龙(去甲雄三烯醇酮,trenbolone)在MsTFA,MBTFA,MO-MSTFA衍生化后形成的TMS醚式和TFA酯化产物,经GC/MSD分析,获得各自的特征图谱,讨论了有关的衍生化问题。群勃龙阳性尿样分析结果显示,其主要代谢产物是表群勃龙(epitrenbolone)和可能的羟基群勃龙(hydroxy-trenbolone),另有少量原型以及可能有去甲雄三烯二酮(triendione)存在。
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| 关 键 词： | 群勃龙 衍生化反应 尿样分析 GC/MSD |
| 收稿时间： | 1993-04-07 |
TRENBOLONE AND ITS METABOLITES IN HUMAN URINE BY GC/MS ANALYSIS |
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| L Ye,CJ Zhang,YZ Zhang and X Liu. TRENBOLONE AND ITS METABOLITES IN HUMAN URINE BY GC/MS ANALYSIS[J]. Acta pharmaceutica Sinica, 1994, 29(1): 61-67 |
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| Authors: | L Ye CJ Zhang YZ Zhang X Liu |
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| Abstract: | The gas chromatography/mass spectrometric properties of trimethylsilyl ether andtrifluoroacetyl ester derivatives of trenbolone,combined with a methoxine group ,are presented.Thecleavage mechanism and some derivatization problems were observed and discussed.The positive urineof trenbolone acetate was checked with the results of epitrenbolone and possible hydroxy-trenbolone asmain metabolites.Also a little trenbolone and possible estra-4,9,11-trien-3,17-dione were found. |
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| Keywords: | Trenbolone Derivatization Urinary analysis GC/MS |
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