| 吡唑烷酮类化合物的抗惊厥作用 |
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| 引用本文： | 刘菊芳,裴印权,王振东,徐建国,雷小平,凌仰之. 吡唑烷酮类化合物的抗惊厥作用[J]. 药学学报, 1994, 29(3): 166-170 |
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| 作者姓名： | 刘菊芳 裴印权 王振东 徐建国 雷小平 凌仰之 |
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| 作者单位： | 北京医科大学药理教研室，成都卫校药理教研室，乌鲁木齐市医院制剂室，北京医科大学药化教研室 |
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| 基金项目： | 国家医药管理局和中国自然科学基金 |
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| 摘 要： | 对3类14种吡唑烷酮类化合物的抗惊厥作用进行了比较研究,它们对最大电休克惊厥均有对抗作用,作用出现快,但维持时间较短,其中II-f作用最强,对听源性发作和家兔海马注射硫酸锌形成的慢性癫痫模型也有效。此外,III-类尚能对抗戊四唑引起的阵挛性惊厥。
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| 关 键 词： | 吡唑烷酮类 抗惊厥作用 |
| 收稿时间： | 1993-06-07 |
STUDIES ON THE ANTICONVULSIVE ACTIVITY OF PYRAZ0LIDINONES |
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| JF Liu,YQ Pei,ZD Wang,JG Xu,XP Lei and YZ Ling. STUDIES ON THE ANTICONVULSIVE ACTIVITY OF PYRAZ0LIDINONES[J]. Acta pharmaceutica Sinica, 1994, 29(3): 166-170 |
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| Authors: | JF Liu YQ Pei ZD Wang JG Xu XP Lei YZ Ling |
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| Abstract: | The anticonvulsive activity of three kinds of pyrazolidinones:5-benzyl- substitut-ed-3-pyrazolidinones;5-benzyl-1-alkyl substituted and 1-alkyl substituted-3-pyrazolidinones werestudied. Fourteen substitutes of these three kinds of pyrazolidinones were found to be potent anticonvul-sants.In doses less than TD50,they were found to be able to protect mice and rats from seizuresproduced by maximal electroshock seizure(MES),such action appeared rapidly and lasted for a shortperiod。II-f was shown to be the most potent anti-MES agent among these three kinds of pyrazolidi-nones.It also showed therapeutic effect in treating experimental epilepsy produced by intrahippocam-pal injection of zinc sulfate in rabbits and audiogenic seizures in rats.The third kind of pyrazolidinonesa1so showed anti-metrazol induced seizures in mice. |
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| Keywords: | Anticonvulsive activity Pyrazolidinones |
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