| 白细胞三烯拮抗剂ONO-1078对豚鼠迷走神经电刺激引起气道痉挛及微血管渗漏作用 |
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| 引用本文： | 魏尔清,王瑶尘,陈丽萍,唐法娣,卞如濂.白细胞三烯拮抗剂ONO-1078对豚鼠迷走神经电刺激引起气道痉挛及微血管渗漏作用[J].药学学报,1994,29(7):487-491. |
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| 作者姓名： | 魏尔清 王瑶尘 陈丽萍 唐法娣 卞如濂 |
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| 作者单位： | 浙江医科大学药理学教研室,杭州310006 |
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| 摘 要： | 阿托品预先处理的豚鼠,电刺激迷走神经(10Hz,5ms,2V或10V,90s)引起气道阻力增高,气管、主支气管和肺内气道的依文思蓝渗出量增加,并随刺激强度加大而增强。白细胞三烯拮抗剂ONO-1078(0.03,0.1mg·kg-1,iv)对气道阻力的增高无明显影响;但显著抑制微血管渗漏,在刺激强度低(2V)时更明显。结果提示白细胞三烯类参与神经原性炎症时的气道微血管渗漏反应。
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| 关 键 词： | 4-氧-8-[对-(4-苯丁氧基)苯甲酰氨基]-2-(5-四唑基)-4H-1-苯并吡喃半水合物(ON |
| 收稿时间： | 1993-11-22 |
EFFECT OF A LEUKOTIENE ANTAGONIST,ONO-1078,ON ELEC-TRIC STIMULATION OF VAGUS(ESV)-INDUCED DRONCHO CONSTRICTION AND MICROVASCULAR LEAKAGE IN GUINEAPIGSEQ |
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| Wei,YCwang,LP Chen,FD Tang and RL Bian.EFFECT OF A LEUKOTIENE ANTAGONIST,ONO-1078,ON ELEC-TRIC STIMULATION OF VAGUS(ESV)-INDUCED DRONCHO CONSTRICTION AND MICROVASCULAR LEAKAGE IN GUINEAPIGSEQ[J].Acta Pharmaceutica Sinica,1994,29(7):487-491. |
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| Authors: | Wei YCwang LP Chen FD Tang and RL Bian |
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| Abstract: | In atropine-pretreated guinea pigs, electric stimulation of vagus(ESV,10 Hz,5ms,2V or 10V,for 90s)increased intrapulmonary pressure(IPP),and Evans blue extravasationin trachea,main bronchi,peripheral and distal intrapulmonary airways in a voltage-dependentmanner.ONO-1078,a noval leukotriene antagonist,(0.03 and0.1mg·kg-1,iv)showed noremarkable inhibiting effect on ESV-induced increase of IPP.However,the agent significantlyinhihited ESV-induced increase of Evans blue extravasation in the airways,especially in lower potencyof stimulation(2V).The results suggest that leukotrienes may be involved in airway microvascularleakage in response to neurogenic inflammation. |
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| Keywords: | Leukotriene Electric stimulation of vagus Microvascularpermeability 4-Oxo-8-[p-(4-phenylbutyloxy)benzoylamino]-2-(tetrazol-5-yl)-4H-1-benzo-pyran hemihydrate(ONO-1078) |
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