| 多巴丝肼联合dl-3-正丁基苯酞胶囊对脑卒中患者患侧肢体功能的影响 |
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| 引用本文： | 马玉强,王凤学,高玉翠,佟志云,张建新,郝立科.多巴丝肼联合dl-3-正丁基苯酞胶囊对脑卒中患者患侧肢体功能的影响[J].中国综合临床,2014(7):683-685. |
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| 作者姓名： | 马玉强 王凤学 高玉翠 佟志云 张建新 郝立科 |
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| 作者单位： | [1]河北省唐山市人民医院神经内科,063000 [2]乐亭县妇幼保健院 ,063000 [3]唐山市古冶区医院 ,063000 [4]唐山市路南区农合办公室,063000 |
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| 基金项目： | 唐山市科学技术研究与发展指导计划项目（13130272b） |
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| 摘 要： | 目的：观察多巴丝肼联合 dl-3-正丁基苯酞胶囊对脑卒中患者患侧肢体功能的影响。方法将90例脑卒中偏瘫患者采用随机数字表法分为康复组、治疗组及对照组，每组30例。前两组患者均给予运动疗法，治疗组患者加用口服多巴丝肼及 dl-3-正丁基苯酞胶囊治疗，对照组仅给予安慰剂口服治疗。分别于治疗前、治疗8周时采用成人偏瘫运动功能评分（FMA）和运动功能评估量表（MAS）对患者下肢功能进行评定。结果治疗前3组患者下肢 FMA康复组（22.6±3.6）分，治疗组（23.1±2.5）分，对照组（20.3±2.9）分]和 MAS 评分分别为（1.6±0.6）、（2.1±0.5）、（1.7±0.9）分]差异均无统计学意义（F =1.64，P ＞0.05；F =1.66，P ＞0.05）；治疗8周后，康复组和治疗组患者下肢 FMA（60.6±3.5）分、（75.7±4.5）分]及 MAS（14.6±1.1）分、（17.7±4.5）分]评分均较治疗前改善（t 值分别为1.738、1.732，1.716、1.732，P 均＜0.05），治疗组较康复组改善（ P 均＜0.05），且两组均优于对照组（31.0＆amp;nbsp；±3.6）、（5.5±1.1）分]，差异均有统计学意义（P 均＜0.05）。结论多巴丝肼联合 dl-3-正丁基苯酞胶囊可进一步改善脑卒中患者患侧肢体功能。
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| 关 键 词： | 脑卒中 运动疗法 多巴丝肼 dl-3-正丁基苯酞胶囊 |
Clinical effects of levodopa benserazide combine with dl-3-butylphthalide capsules on limbs function of patients after stroke |
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| Ma Yuqiang,Wang fengxue,Gao yucui,Tong Zhiyun,Zhang Jianxin,Hao Like.Clinical effects of levodopa benserazide combine with dl-3-butylphthalide capsules on limbs function of patients after stroke[J].Clinical Medicine of China,2014(7):683-685. |
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| Authors: | Ma Yuqiang Wang fengxue Gao yucui Tong Zhiyun Zhang Jianxin Hao Like |
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| Institution: | (Neurology Department, the People＇s Hospital of Tangshan, Tangshan 063000, China) |
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| Abstract: | Objective To investigate the effects of levodopa benserazide hydrochloride combine with dl-3-butyl phthalide capsule on patient＆#39;s limbs function after stroke. Methods Ninety patients with stroke were randomly divided into rehabilitation group,treatment group and control group,and 30 cases for each group. Patients in rehabilitation group were treated with exercise therapy,in treatment group were given exercise therapy and levodopa Benserazide and Dl-3-butylphthalide capsules,and in control group were given placebo treatment. Adult hemiplegic motor function score（FMA）and motor function assessment scale（MAS）were used to assess the motor function and lower extremity function before treatment and 8 weeks after treatment. Results Before treatment,FMA and MAS in rehabilitation group,treatment group and control group were（22. 6 ± 3. 6）, （23. 1 ± 2. 5）and（20. 3 ± 2. 9）,and（1. 6 ± 0. 6）,（2. 1 ± 0. 5）,（1. 7 ± 0. 9）,respectively. There was no significant differences between the two groups（ F = 1. 64,P 〉 0. 05;F = 1. 66,P 〉 0. 05）. After 8 weeks of treatment,FMA and MAS in rehabilitation group and treatment group were（60. 6 ± 3. 5）,（14. 6 ± 1. 1）,and （75. 7 ± 4. 5）,（17. 7 ± 4. 5）,significant improved more than that before treatment（t = 1. 738,1,716,1. 732 respectively;P 〈 0. 05）. Meanwhile,patients in the treatment group improved more than that in rehabilitation group（P 〈 0. 05）,and they were superior to patients in control group（（31. 0 ± 3. 6）,（5. 5 ± 1. 1）;P 〈 0. 05）. Conclusion Benserazide combined with dl-3- butyl phthalide capsule can further improve the limbs function. |
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| Keywords: | Stroke Exercise therapy Levodopa benserazide Dl-3- butyl phthalide capsule |
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