利拉鲁肽和盐酸二甲双胍对血糖控制不佳的超重初发糖尿病患者的效果观察

目的观察对血糖控制不佳的超重初发糖尿病患者分别应用盐酸二甲双胍、利拉鲁肽进行降糖治疗后血糖变化的情况。方法将44例血糖控制不佳的超重初发2型糖尿病患者随机分为对照组、利拉鲁肽组及盐酸二甲双胍组，分别给予饮食和运动控制、利拉鲁肽皮下注射以及盐酸二甲双胍口服治疗等措施，观察时间为12周，对比治疗前、后患者的体质量指数（BMI）、空腹血糖（FBG）及餐后2h血糖（2hPBG）、糖化血红蛋白（HbAlc）浓度。结果治疗后利拉鲁肽组和盐酸二甲双胍组患者的FBG、2hPBG及HbAlc较治疗前均有降低，且与对照组治疗后比较，差异均有统计学意义（P均〈0．05）；利拉鲁肽组的BMI（24．61±3．47）kg／m2]较对照组（25．37±4．70）kg／m2]明显降低，差异有统计学意义（P〈0．05）；利拉鲁肽组的2hPBG（7．13±3．85）mmol／L]比盐酸二甲双胍组（8．03±4．33）mmol／L]明显降低，差异有统计学意义（P〈0．05）；盐酸二甲双胍组的FBG（6．31±3．45）mmol／L]和利拉鲁肽组（6．98±2．97）mmol／L]相比有降低，但差异无统计学意义（P〉0．05）。结论利拉鲁肽和盐酸二甲双胍片均可有效的降低超重糖尿病患者体质量指数及血糖，利拉鲁肽较盐酸二甲双胍片能更加明显的降低餐后血糖及患者体质量指数。

Clinical effect of liraglutide and metformin hydrochioride on overweight diabetic patients due to poorglycemic control

Objective To investigate the effect of liraglutide and metformin hydrochioride on overweight diabetic patients because of poor glycemic control. Methods Forty-four overweight patients with poor glycemic control were randomly dMded to the control group, the liraglutide group and the mefformin hydrochioride group. Patients in control group were given diet and exercise control, in liraglutide group and the metformin hydrochioride group were given subcutaneous injection liraglutide, metformin hydrochioride oral treatment respectively for 12 weeks. Body mass index （ BMI）, fasting blood glucose （ FBG）, 2-hour postprandial blood glucose （2 hPBG） and glycosylated hemoglobin （HbAlc） were measured. Results Compared with pre- treatment,FBG,2 hPBG and HbAlc of patients in liraglutide group and metformin hydrochioride group were lower after treatment, and there was significant difference between the two group and the control group after treatment （P 〈 0. 05 ）. BMI of patients in liraglutide group was （24. 61± 3.47） kg/m2,lower than of the control group（ （25. 37 ±4. 70） kg/m2, P 〈 0. 05 ）. 2 hPBG of patients in the liraglutide group was （ 7. 13 ± 3. 85 ） mmol/L, lower than that of the metformin hydrochioride group（ （8. 03 ± 4. 33 ） mmol/L,P 〈 O. 05 ）. FBG level in metformin hydrochioride group （ （6. 31 ± 3.45 ） mmol/L） was lower than that of the liraglutide group（ （6.98 ± 2. 97 ） mmol/L）, but the difference was not statistically significant （ P 〉 0.05 ）. Conclusion Liraglutide and metformin hydrochioride treatment can effectively reduce weight and blood sugar of the overweight diabetics. The effect of liraglutide to reduce postprandial blood glucose and weight of the patient is more significant than of metformin hydrochioride.