冠状动脉介入治疗对冠心病患者血浆单核细胞趋化因子1和基质金属蛋白酶9的影响

目的：探讨冠心病患者行冠状动脉介入（PCI）治疗前后血浆单核细胞趋化因子1（MCP-1）及基质金属蛋白酶9（MMP-9）的改变。方法连续入选经冠状动脉造影证实单支病变的冠心病患者50例（PCI 组），冠状动脉正常者30例（对照组），检测对照组造影前后和 PCI 组介入前后血浆 MCP-1和MMP-1，比较两组间的差异。结果（1）PCI 组患者介入后血浆 MCP-1为（19.87±5.31）ng/ L，介入术前为（15.71±5.23）ng/ L，差异有统计学意义（t =3.95，P ＜0.01）；对照组冠状动脉造影术后 MCP-1为（13.78±5.58）ng/ L，术前为（12.42±5.39）ng/ L，差异无统计学意义（P =0.34）。（2）PCI 组患者介入术后血浆 MMP-9为（22.69±5.97）mg/ L，术前为（19.52±5.72）mg/ L，差异有统计学意义（t =2.71，P＜0.01）；对照组冠状动脉造影术后 MMP-9为（17.53±5.51）mg/ L，造影术前为（16.69±5.42）mg/ L，差异无统计学意义（P =0.55）。结论 PCI 促进冠心病患者血浆 MCP-1及 MMP-1水平的升高，是否为介入治疗术后支架内再狭窄的重要机制之一尚待进一步考证。

Effect of plasma monocyte chemotactic factor-1 protein and matrix metalloproteinase-9 of patients with coronary artery disease following percutaneous coronary interventional procedures therapy

Objective To explore the change of monocyte chemotactic factor-1 protein（MCP-1）and matrix metalloproteinase-9（ MMP-9）of patients with coronary artery disease（ CAD）following percutaneous coronary interventional（ PCI）. Methods Fifty patients underwent PCI procedures for CAD compromising a single coronary artery were selected as PCI group and 30 healthy individuals with normal findings by coronary angiography were selected as the control group. Plasma MCP-1 and MMP-9 were measured in all the subjects. Results The plasma MCP-1 level of patients with CAD after PCI was（19. 87 ± 5. 31）ng/ L,higher than that before operation（（15. 71 ± 5. 23）ng/ L,t = 3. 95,P 〈 0. 01）. Whereas in the control group,the MCP-1 level after coronary angiography was（13. 78 ± 5. 58）ng/ L,which was as same as that before operation （12. 42 ± 5. 39 ng/ L,P = 0. 34）. Plasma MMP-9 level in the CAD patients after PCI procedures was（22. 69 ± 5. 97）mg/ L,higher than that before operation（（19. 52 ± 5. 72）mg/ L,t = 2. 71,P 〈 0. 01）. There was no significant difference in term of plasma MMP-9 level in control group befor and after operation（（17. 53 ± 5. 51） mg/ L vs.（16. 69 ± 5. 42）mg/ L,P = 0. 55）. Conclusion Plasma MCP-1 and MMP-9 increase in CAD patients following PCI procedures. But their roles in the vascular restenosis following the procedures need further investigation.