生长分化因子-15与正常高值血压者左室重构的相关性分析

目的 对比观察生长分化因子-15 （GDF-15）在理想血压、正常高值血压人群中的浓度变化及其与部分左室重构指标的相关性.方法 以2011年10月～2013年3月在我院体检中心参加体检的200例正常高值血压者为研究对象,以同期体检的100例理想血压者作为对照,应用彩色多普勒超声测定左心室质量指数（LVMI）,抽取空腹静脉血测定GDF-15以及其它生化指标.并用Pearson相关性分析正常高值血压者的血清GDF-15与其它指标的相关性.结果 正常高值血压组收缩压、舒张压、GDF-15、LVMI明显高于理想血压组,两组比较差异有统计学意义（P＜0.01或0.05）.正常高值血压组GDF-15与收缩压（r=0.412,P＜0.01）、舒张压（r=0.263,P＜0.01）、LVMI（r =0.520,P＜0.01）呈正相关.结论 GDF-15在正常高值血压人群中浓度即开始升高,可能与其左室重构具有一定的相关性.

The correlation between growth differentiation factor-15 with left ventricular remodeling in people with high-normal blood pressure

Objective To observe the concentration changes of growth differentiation factor-15 （GDF-15） in people with ideal blood pressure and high-normal blood pressure,as well as the correlation with some indicators about left ventrieular remodeling, and discuss the significance. Methods To select 200 cases with high-normal blood pressure that had done physical examination in the examination center of our hospital from May 2011 to Aug 2013 for the study,and took 100 cases with ideal blood pressure that had done physical examination in the same period as control group, then to collect the general clinical da- ta,and detect left ventricular mass index（LVMI） by color Doppler ultrasound, and collect GDF-15 con- centration of serum, as well as other biochemical markers. Then to analysis the relevance between GDF-15 of serum and other indicators in people with high-normal blood pressure by the pearson correlation analy- sis. Results SBP, DBP, GDF-15 and LVMI in people with high-normal blood pressure group were signifi- cantly higher than the ideal blood pressure group, and the differences were statistically significant （ P 〈 0.01 or 0.05 ）. The GDF-15 was positively correlated with SBP（ r = 0. 412, P 〈 0.01 ）, DBP（ r = 0. 263, P 〈 0.01 ） ,and LVMI（r = 0. 520,P 〈 0.01 ）. Conclusion GDF-15 concentration began to rise in people with high-normal blood pressure, that may be associated with the left ventricular remodeling.