血浆髓过氧化物酶对稳定型心绞痛患者心血管事件的预测作用

目的 探讨血浆髓过氧化物酶（MPO）对稳定型心绞痛患者远期心脏事件的预测作用.方法 选择稳定型心绞痛患者247例,分别检测血浆MPO、超敏C反应蛋白（hs-CRP）,随访2年,观察不同血浆MPO水平患者冠心病（冠状动脉狭窄＞50％）主要心血管不良事件（MACES,包括死亡、心肌梗死、卒中等）的发生情况.结果 247例患者按血浆MPO水平行二分位数法分组分为MPO＞ 320 mg/L组84例和MPO≤320 mg/L组163例,血浆MPO＞ 320 mg/L者MACES发生风险明显增加（HR=1.67,95％ CI：1.32～2.57,P＜0.05）.血浆MPO与hs-CRP浓度成正相关（r=0.132,P＜0.05）.结论 血浆MPO浓度能在稳定型心绞痛患者中独立预测长期主要心血管不良事件的发生,在预测主要心血管不良事件发生的风险因子中,hs-CRP与血浆MPO浓度存在相关性.

Prediction of plasma myeloperoxidase on cardiovascular event of patients with stable angina pectoris

Objective To explore the independent prognostic value of plasma myeloperoxidase （MPO） in cardiovascular event of patient with stable angina pectoris.Methods Two hundred and forty-seven patients with stable angina pectoris （defined as 50％ stenosis in any coronary vessel） were selected as our subjects and they all were followed up for 2 years.Plasma MPO and hsCRP concentrations were measured.The major adverse cardiovascular events （MACEs）,including death,myocardial infarction and stroke,occurred in patients were recorded.Results All patients were divided into high MPO group （84 cases and plasma MPO concentrations over 320 mg/L） and low MPO group （163 cases,plasma MPO concentrations less than 320 mg/L）.Compared with patients in low MPO group,the risk of occurring MACEs in high MPO group was higher（HR =1.67,95％ CI =1.32-2.57,P ＜ 0.05）.There was positive correlation between plasma MPO and hsCRP concentrations （r =0.132,P ＜ 0.05）.Conclusion MPO level may serve as a better prediction index for adverse cardiovascular events of patients with Stable angina pectorisindependently.MPO has relationship with hsCRP concentrations.