新疆维吾尔族男性高尿酸血症与代谢综合征相关性研究

目的 了解新疆维吾尔族男性高尿酸血症与代谢综合征的相关性.方法 对791例维吾尔族男性体检者的体重、身高、腰围、臀围、舒张压（DBP）、收缩压（SBP）进行测量,并检测相关血液生化指标,包括血尿酸（SUA）、空腹血糖（FBG）、三酰甘油（TG）、总胆固醇（TC）、低密度脂蛋白-胆固醇（LDL-C）、高密度脂蛋白-胆固醇（HDL-C）.结果 此次研究人群中代谢综合征的检出率为18.33％,高尿酸血症检出率为39.95％.高尿酸组患者体质指数（BMI）、腰臀比（WHR）、DBP、SBP、FBG、TC、TG、LDL-C与代谢综合征组的相关指标均高于尿酸正常组,并与血尿酸水平密切相关：高尿酸组与尿酸正常组比较,腹部脂肪堆积、肥胖、高血糖、高三酰甘油血症、高血压的检出率比较差异有统计学意义（P＜0.05）.高尿酸组出现腹部脂肪堆积、肥胖、高血糖、高三酰甘油血症、高血压的风险分别为尿酸正常组的2.126、3.002、2.413、2.903和2.101倍（P＜0.05）.结论 腹部脂肪堆积、肥胖、高血糖、高三酰甘油血症、高血压等代谢综合征相关危险因子是新疆维吾尔族男性发生高尿酸血症的危险因素,应加强对高尿酸血症及代谢综合症患者的健康教育.

The correlation study of hyperuricemia and metabolic syndromes among males of Uighur ethnicity in Xinjiang

Objective To investigate the relationship between serum uric acid（UA） and metabolic syndrome（MS） among males of Uighur ethnicity in Xinjiang.Methods The blood samples were collected from May to December 2012 in Urumqi,it included 791 subjects.These subjects were analyzed for serum uric acid（SUA）,the fasting blood glucose （FBG）,serum triglyceride （TG）,serum total cho1eslerol （TC）,serum high density lipoprotein （HDL-C）,and serum low density lipoprotein （LDL-C） as well as biochemistry targets.Data were analyzed using the Pearson chi-square test and Mann-Whitney Test and the Mantel-Haenszel test for linear trend respectively.Results The prevalence of hyperuricemia and MS in the present study were 39.95％ and 18.33％,Blood pressure,FBG,body mass index（BMI）,waist/hip ratio,TG,TC,LDL-C were significantly higher in peoples with hyperuricemia than in normal persons and these factors were strongly related to serum uric acid too,The components of metabolic syndrome such as fat,hyperglycemia,hypertension,dyslipidemia were showed closely correlated with SUA.The Odds ratios of these metabolic diseases in hyperuricemia group were 3.002,2.126,2.413,2.101,2.903-times to SUA normal group respectively.Conclusion Hyperuricemia is closely linked to the various components of the metabolic syndrome,more emphasis should be put on the evolving control and prevalence of hyperuricemia and metabolic syndrome among males of Uighur ethnicity in Xinjiang.