血浆睾酮水平对中青年男性2型糖尿病患者罹患代谢综合征的影响 |
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引用本文: | 李新,杨杪,孙苏欣,吴玉文,孙家忠.血浆睾酮水平对中青年男性2型糖尿病患者罹患代谢综合征的影响[J].临床内科杂志,2014(2):105-107. |
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作者姓名: | 李新 杨杪 孙苏欣 吴玉文 孙家忠 |
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作者单位: | 武汉大学中南医院内分泌科,430071 |
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摘 要: | 目的 探讨血浆睾酮水平对中青年男性2型糖尿病(T2DM)患者罹患代谢综合征(MS)的影响.方法 共纳入220例年龄在18 ~50岁的男性2型糖尿病患者,按照血浆睾酮浓度四分位分组,搜集一般资料、吸烟史及人体测量学指标,检测患者空腹血糖、空腹胰岛素、血脂、糖化血红蛋白(HbAlc)水平.结果 随血浆睾酮浓度升高,MS发病率下降(P<0.05),吸烟者比例、年龄、糖尿病病程、腰围、体重指数(BMI)、收缩压(SBP)、舒张压(DBP)、HbAlc、HOMA-IR、三酰甘油(TG)、总胆固醇(TC)及低密度脂蛋白胆固醇(LDL-C)等均降低(P<0.01或P<0.05).相关性分析显示,血浆睾酮浓度与年龄、吸烟、糖尿病病程、腰围、BMI、SBP、DBP、HbAlc、HOMA-IR、TG、TC及LDL-C等均呈负相关(P<0.01或P<0.05).Logistic回归分析显示,血浆睾酮为中青年男性2型糖尿病患者罹患MS的保护性因素,其OR值为0.479(95%CI:0.249 ~0.936,P<0.01),在校正年龄、吸烟、糖尿病病程、HOMA-IR及HbAlc后其OR值上升为0.759(95%CI:0.598 ~ 0.963,P<0.05).结论 中青年男性2型糖尿病患者血浆睾酮水平与代谢综合征呈负相关,低血浆睾酮可能是其罹患谢综合征的独立危险因素.
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关 键 词: | 睾酮 2型糖尿病 代谢综合征 中青年 男性 |
Impacts of the serum testosterone on the metabolic syndrome in young and middle-aged men with type 2 diabetes mellitus |
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Institution: | LI Xin, YANG Miao, SUN Suxin, et al. Department of Endocrinology, Zhongnan Hospital, Wuhan University, Wuhan 430071 ,China |
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Abstract: | Objective To investigate the impacts of the serum testosterone on the metabolic syndrome(MS) in young and middle-aged men with type 2 diabetes mellitus (T2DM). Methods A total of 220 young and middle-aged(18-50) men with T2DM were recruited in this study and were divided into four groups based on serum T quartile. General information, smoking history and anthropometry data were collected. Fasting glucose, fasting insulin, blood fat and HbA1 c were detected. Results With the increas- ing of T concentration,the incidence of MS was decreased(P 〈 0.05 ) ,together with the decrease of age, smoking, course of T2DM, waist circumference, body mass index ( BMI ), systolic blood pressure ( SBP), diastolic blood pressure ( DBP), HbA1 c, HOMA-IR, total cholesterol ( TC ), tfiglyceride ( TG ), low density lipoproteins cholesterol ( LDL-C ) ( all P 〈 0. 05 or P 〈 0.01 ). Spearman correlation analyze indicated that serum T was negatively correlated with age, smoking, course of T2DM, waist circumference, BMI, SBP, DBP, HbA1 e, HOMA-IR, TG, TC, LDL-C ( all P 〈 0. 05 or P 〈 0.01 ). Logistic regression analyze indicated that serum T was a protective factor of MS in young and middle-aged men with T2DM (OR = 0.479,95 % CI:0. 249-0. 936, P 〈 0.01 ). After the adjustment of age, smoking, course of T2DM, HOMA-IR and HbAlc,the OR was 0.759(95% CI:0. 598-0. 963 ,P 〈 0.05 ). Conclusion The serum T in young and middle-aged men with T2DM was negatively correlated with MS. Low serum T may be an independent risk factor of MS in such patients. |
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Keywords: | Testosterone Type 2 diabetes mellitus Metabolic syndrome Young and middle-aged Male |
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