Graves病与低钾性周期性麻痹和胸腺增生的关系

目的 观察Graves病与低钾性周期性麻痹和胸腺增生的关系.方法 收集2010年1月至2011年1月临床确诊的Graves病患者62例分为两组：Graves病不伴胸腺增生组33例;Graves病伴胸腺增生组29例,同期门诊体检健康人为正常对照组30名.结果 Graves病伴胸腺增生组与不伴胸腺增生组相比,在性别、年龄、病程、是否伴有甲状腺肿大、突眼、周期性麻痹及血清游离三碘甲状腺原氨酸、血清游离甲状腺素、促甲状腺素方面,差异均无统计学意义（P均＞0.05）,正常对照组均无胸腺增生;男性Graves病伴胸腺增生患者周期性麻痹发生率62％ （8/13）,明显高于女性6％ （1/16）,差异有统计学意义（x2=10.24,P＜0.05）;男性Graves病患者周期性麻痹发生率62％（16/26）,明显高于女性6％（2/36）,差异有统计学意义（x2=22.96,P＜0.05）;Graves病患者是否伴胸腺增生与性别、年龄、病程、是否伴有甲状腺肿大、突眼、周期性麻痹及游离三碘甲状腺原氨酸、血清游离甲状腺素、促甲状腺激素无相关性（P均＞0.05）.结论 男性Graves病伴胸腺增生患者周期性麻痹发生率高于女性,在临床工作中应予鉴别,以免漏诊误诊.

The association between Graves disease with hypokalemic periodic paralysis or thymus hyperplasia

Objective To explore the relationship between Graves disease and hypokalemic periodic paralysis or thymus hyperplasia.Methods Sixty-two patients with Graves disease were enrolled in this study.Thirty-three patients without thymus hyperplasia were selected as group A and other 29 patients were group B.In addition,30 healthy volunteers served as control group.Results There were no significant difference between group A and group B in terms of sex,age,illness course,thyroid enlargement,exophthalmos,periodic paralysis and the levels of free triiodothyronine （FT3）,free thyroxin （FT4）,thyroid stimulating hormone （TSH） （P ＞ 0.05）.The incidence rate of hypokalemic periodic paralysis in male Graves disease with thymus hyperplasia was 62％ （8/13）,higher than that in female patients （6％ （1/16）,x2 =10.24,P ＜ 0.05）.The incidence rate of hypokalemic periodic paralysis in male Graves patients was 62％ （16/26）,higher than in female Graves patients （6％ （2/36）,x2 =22.96,P ＜ 0.05）.There was no significant relationship between Graves disease patients combined with thymus hyperplasia and sex,age,illness course,thyroid enlargement,exophthalmos,periodic paralysis and the levels of FY3,FT4,TSH.Conclusion The incidence rate of hypokalemic periodic paralysis in male Graves disease patients combind with thymus hyperplasia is higher than in female,and therefore it should pay more attention of male Graves patients in case misdiagnosis.