Evidence that blockade of post-synaptic 5-HT1 receptors elicits feeding in satiated rats |
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Authors: | C. T. Dourish M. L. Clark A. Fletcher S. D. Iversen |
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Affiliation: | (1) Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Terlings Park, Eastwick Road, CM20 2QR Harlow, Esse, UK;(2) Department of Biomedical Research, Wyeth Research (UK), Huntercombe Lane South, Taplow, SL6 OPH Nr. Maidenhead, Berks, UK |
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Abstract: | The effects of nine central 5-HT antagonists on food intake in free feeding male rats were examined. The 5-HT2 antagonists ritanserin and ketanserin and the selective 5-HT3 antagonists ICS 205-930 and MDL 72222 had no effect on food intake. In contrast, the non-selective 5-HT antagonists metergoline, methiothepin, mesulergine, mianserin and methysergide (all of which have high affinity for various 5-HT1 receptor subtypes), dose-dependently increased food intake during a 4-h daytime test. Furthermore, metergoline dose dependently increased food intake over a 24-h period. Suprisingly, mesulergine decreased food intake over a 24-h period at the same doses that increased daytime food intake. This may indicate that the increase in daytime feeding produced by mesulergine is a non-specific response. Although the antagonists used have varying degrees of selectivity for 5-HT receptor subtypes, the pattern of results suggests that postsynaptic 5-HT1 receptors (possibly of the 5-HT1C type) play an important role in the control of feeding in rats. |
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Keywords: | Feeding 5-HT antagonists 5-HT1 receptors 5-HT1C receptors Rat |
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