Islet Cell and Other Organ-specific Autoantibodies in Healthy First-degree Relatives to Insulin-dependent |
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| Authors: | B HÅGGLÖF A RABINOVITCH P MACKAY A HUEN A H RUBENSTEIN B MARNER J NERUP Å LERNMARK |
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| Institution: | Department of Paediatrics, University of Umeå, Umeå, Sweden;Hagedorn Research Laboratory, Gentofte, Denmark;Department of Medicine, University of Chicago, Chicago, Illinois, USA;Steno Memorial Hospital, Gentofte, Denmark |
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| Abstract: | ABSTRACT. The presence of organ-specific autoantibodies including islet cell surface, cytoplasmic and cytotoxic as well as thyroid-gastric antibodies were determined in healthy, non-diabetic, first-degree relatives to 30 insulin-dependent diabetic (IDDM) children. Thirty healthy families without family-history of diabetes mellitus served as controls. The prevalence of organ-specific autoantibodies among the healthy members in the diabetic families was increased compared to the control families ( p <0.005). Islet cell cytoplasmic antibodies were only detected in diabetes families, since 23% (7/30) of the probands and 7% (2/31) of the siblings were positive and all others negative. Organ-specific autoantibodies were associated with HLA DR3 only in the diabetes families ( p <0.025) while autoantibody positive members in the control families were associated with HLA B7 ( p <0.01). This study suggests that childhood IDDM occurs in families with an increased prevalence of organ-specific autoantibodies. |
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| Keywords: | Islet cell cytoplasmic antibodies islet cell surface antibodies islet cell cytotoxic antibodies organ-specific autoantibodies isulin-dependent diabetes family members |
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