| 透皮促渗剂对甲氧氯普胺的透皮吸收 |
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| 引用本文： | 陆锦芳,杜一鸣,赵岩松,徐惠南.透皮促渗剂对甲氧氯普胺的透皮吸收[J].复旦学报(医学版),1994(3). |
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| 作者姓名： | 陆锦芳 杜一鸣 赵岩松 徐惠南 |
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| 作者单位： | 上海医科大学药学院药剂学教研室 |
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| 摘 要： | 采用Ｖ－Ｃ水平扩散池研究几种透皮促渗剂对甲氧氯普胺穿透完整小鼠皮肤的作用。实验结果表明：丙二醇、油酸、氮酮与丙二醇混合物均能增加甲氧氯普胺的穿透作用，特别是氮酮与丙二醇混合物使甲氧氯普胺透过小鼠皮肤的穿透系数增加５～６倍。
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| 关 键 词： | 甲氧氯普胺 透皮促渗剂 穿透系数 氮酮 油酸 丙二醇 |
THE EFFECT OF PENETRATION ENHANCERS ON THE TRANSDERMAL ABSORPTION OF METOCLOPRAMIDE |
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| Lu Jinfang,Du Yiming,Zhao Yansong,Xu Huinan.THE EFFECT OF PENETRATION ENHANCERS ON THE TRANSDERMAL ABSORPTION OF METOCLOPRAMIDE[J].Fudan University Journal of Medical Sciences,1994(3). |
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| Authors: | Lu Jinfang Du Yiming Zhao Yansong Xu Huinan |
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| Abstract: | V-C horizontal diffusion cell was used to measure the transfer of metoclopramide across intact abdominal mouse skin in vitro.The effect of penetration enhancers propylene glycol,oleic acid,and azone-propylene glycol on the permeability of metoclopramide was investigated.The results indicated the feasibility of utilization of penetration enhancers to improve the transdermal absorption of metoclopramide:The permeation coefficients of metoclopramide raised with presence of various kinds of transdermal enhancers. |
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| Keywords: | metoclopramide penetration enhancers permeation coefficients azone oleic acid propylene glycol |
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