| 表皮生长因子受体和P53在宫颈鳞癌中的表达 |
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| 引用本文： | 王修珍,顾永平,邓海珍.表皮生长因子受体和P53在宫颈鳞癌中的表达[J].中国现代医药杂志,2003,5(4):13-15. |
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| 作者姓名： | 王修珍 顾永平 邓海珍 |
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| 作者单位： | 215000,苏州大学医学院基础医学系病理教研室 |
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| 摘 要： | 目的研究表皮生长因子受体(EGFR)和P53在宫颈鳞癌组织中的表达及意义。方法采用免疫组化S-法对53例不同分化的宫颈鳞癌组织及10例慢性宫颈炎组织进行EGFR和P53检测。结果10例慢性宫颈炎组织中未发现P53和EGFR阳性表达,53例宫颈鳞癌中EGFR和P53阳性表达率分别为49.0%(26/53)和47.2%(25/53),阳性表达的EGFR定位于肿瘤组织的细胞膜或细胞浆,P53定位于细胞核内。结论EGFR和P53蛋白阳性表达率与宫颈癌的分化程度有关,提示P53蛋白和EGFR参与宫颈癌的发生和发展过程。
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| 关 键 词： | 鳞癌 宫颈 受体 表皮生长因子 蛋白 P53 免疫组织化学 |
| 修稿时间： | 2003年5月11日 |
Expression of EGFR and P53 in cervical carcinoma |
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| Wang Xiuzhen,Gu Yongping,Deng Haizhen.Expression of EGFR and P53 in cervical carcinoma[J].Modern Medicine Journal of China,2003,5(4):13-15. |
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| Authors: | Wang Xiuzhen Gu Yongping Deng Haizhen |
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| Affiliation: | Wang Xiuzhen,Gu Yongping,Deng Haizhen. Department of pathology,Suzhou University Medical college,Jiangsu 215000 |
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| Abstract: | Objective To study the expression and significance of epidermal growth factor receptor (EGFR) and P53 in cervical squamous cell carcinoma. Methods S p immunohistochemical method was adopted to examine the expression of EGFR and P53 in 53 specimans of cervical squamous cell carcinoma and 10 specimans of chronic cervicitis. Results Expressions of EGFR and P53 in chronic cervicitis were negative. The positive rate of EGFR and P53 expressions in cervical squamous cell carcinoma were 49.0% (26/53) and 47.2% (25/53) respectively. The positive expression of EGFR located in cell membrane and cytoplasm, P53 in nucleus. Conclusion Positive expressions of both EGFR and P53 in cervical squamous cell carcinoma relate to the degree of differentiation, and suggest the EGFR and P53 might participate in developing progressing in squamous cell carcinoma of cervix. |
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| Keywords: | Squamous cell carcinoma Cervix Receptor RGFR Protein P53 Immunohistochemistry |
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