Comparative study of BacT/alert FAN bottles and standard BacT/alert bottles |
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| Affiliation: | 1. Department of Microbiology and Infectious Diseases, Foothills Hospital, Calgary, Alberta, Canada;1. Department of Wine, Food and Molecular Biosciences, Lincoln University, Christchurch, New Zealand;2. Riddet Research Institute, Palmerston North, New Zealand;3. Dr. Balasaheb Sawant Konkan Krishi Vidyapeeth, Dapoli, India;4. School of Food Science and Engineering, South China University of Technology, Guangzhou, P.R. China;1. Department of Pathology, The Ohio State University, Columbus, OH 43210, USA;2. Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA;3. Comprehensive Cancer Center and The James Cancer Hospital and Solove Research Institute, The Ohio State University, Columbus, OH 43210, USA;1. Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, USA;2. Department of Immunology and Infectious Disease, The Scripps Research Institute, La Jolla, CA 92037, USA;3. Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA;4. Medicinal Chemistry Research Laboratories, New Drug Research Division, Otsuka Pharmaceutical Co., Ltd., 463-10 Kawauchi-cho, Tokushima 771-0192, Japan;5. Vividion Therapeutics, 5820 Nancy Ridge Drive, San Diego, CA 92121, USA;6. Razavi Newman Integrative Genomics and Bioinformatics Core, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA;7. Chemical Biology and Therapeutics Science Program, Broad Institute, Cambridge, MA 02138, USA;8. Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA |
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| Abstract: | A total of 5,230 paired blood cultures were studied. One sample was divided between aerobic and anaerobic BacT/Alert standard bottles, and the other divided between aerobic and anaerobic BacT/Alert FAN bottles. There were 44 occasions where Staphylococcus aureus was recovered only from the FAN bottles, compared to six where only the standard bottles were positive (p <0.001), and 21 occasions where Escherichia coli was isolated only from FAN bottles, compared to eight occasions where only the standard bottles were positive for this organism (p <0.05). In 21 of 28 cases reviewed where S. aureus was isolated from FAN bottles only the patient had been receiving anti-staphylococcal antibiotics. However, only 2 of 30 cases where Gram-negative bacilli were isolated from FAN bottles had documented recent appropriate antibiotic therapy. Patients in whom FAN bottles are more likely to recover organisms cannot be selected on the basis of documented antibiotic treatment. |
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