早孕妇女血清及绒毛组织中表皮生长因子的含量及米非司酮对其 …

探讨表皮生长因子对早期胚胎发育的影响和米非司酮对胚胎生长及ＥＧＦ的作用。方法 采用放射免疫法测定６６例不同孕龄的早孕妇女血清及毛组织中ＥＧＦ,血雌二醇和孕酮及２０常育龄妇女血清育龄妇女血清ＥＧＦ水平,并观察药物流产时米非司酮对绒毛组织中ＥＧＦ含量的影响。

Effect of mifepristone on the concentration of epidermal growth factor in serum and villi of early pregnant women

OBJECTIVE: To investigate the change of epidermal growth factor (EGF) concentration in serum and villi of early pregnant women and its possible effects by mifepristone. METHODS: Twenty normal women as control and sixty-six early pregnant women were enrolled for study. Serum EGF, estradiol (E2) and progesterone (P) concentrations were measured with radioimmunoassay. EGF concentration in villi by surgical aspiration and mifepristone induced abortion were compared. RESULTS: Serum EGF concentration in early pregnant women was significantly higher than that in non-pregnant women (P < 0.01). The serum EGF, E2 and P concentrations increased as pregnancy advanced (P < 0.05). The growth rate of gestational sac declined and serum EGF and P concentrations decreased slightly after administration of mifepristone. Villi EGF content in mifepristone group was significantly lower than that in surgical group (P < 0.05). CONCLUSION: EGF may be involved in regulating embryo development. Mifepristone may interfere embryonic development via inhibiting EGF level.