Evaluation of Oxidative Stress Parameters and Urinary Deoxypyridinoline Levels in Geriatric Patients with Osteoporosis

[Purpose] To evaluate the oxidative stress parameters and urinary deoxypyridinolinelevels in geriatric patients with osteoporosis. [Subjects and Methods] Eighty geriatricpatients aged over 65 years were recruited. Patients were divided into two groups: Group 1(n=40) consisted of patients with osteoporosis, and Group 2 (n=40) consisted of patientswithout osteoporosis. Bone mineral density measurements were performed for all patientsusing DEXA. Oxidative stress parameters were analyzed in blood samples, anddeoxypyridinoline levels were analyzed in 24-hour urinary samples. [Results] Compared toGroup 2, the total antioxidant status and oxidative stress index levels of Group 1 werenot significantly different; however, total oxidant status and 24-hour urinarydeoxypyridinoline levels were significantly higher. Pearson correlation coefficientsindicated that OSI and urinary deoxypyridinoline levels were not correlated with anybiochemical parameters. ROC-curve analysis revealed that urinary deoxypyridinoline levelsover 30.80 mg/ml predicted osteoporosis with 67% sensitivity and 68% specificity (areaunder the curve = 0.734; %95 CI: 0.624–0.844). [Conclusion] Our results indicate thatoxidative stress would play a role in the pathogenesis of osteoporosis, and that urinarydeoxypyridinoline levels may be a useful screening test for osteoporosis.Key words: Osteoporosis, Oxidative stress index, Deoxypyridinoline