| 青钱柳化学成分及抗代谢性疾病药理作用研究进展 |
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| 引用本文： | 徐若宸,张鹏,向明.青钱柳化学成分及抗代谢性疾病药理作用研究进展[J].中草药,2023,54(9):2962-2977. |
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| 作者姓名： | 徐若宸 张鹏 向明 |
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| 作者单位： | 华中科技大学同济医学院药学院生物药学系, 湖北 武汉 430000;华中科技大学同济医学院药学院 中药与天然药物学系, 湖北 武汉 430000;湖北省天然药物化学与资源评价重点实验室, 湖北 武汉 430000;华中科技大学同济医学院药学院生物药学系, 湖北 武汉 430000;湖北省天然药物化学与资源评价重点实验室, 湖北 武汉 430000 |
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| 基金项目： | 2022年湖北省科技计划项目（2022BEC052） |
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| 摘 要： | 桑黄是一类珍稀药用真菌,其有效成分主要是酚类化合物,包括黄酮、苯乙烯α-吡喃酮、苯丙素、异香豆素及其他酚类化合物。这些有效成分通常以回流、超声等方法来提取,并利用大孔树脂进行纯化。桑黄中的单体成分及有效部位具有抗氧化、抗肿瘤、调节免疫等多种药理作用。通过对药材"桑黄"中化学成分的结构类型和特征、提取纯化方法及其药理作用进行综述,为桑黄的开发及应用提供理论基础。
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| 关 键 词： | 青钱柳 三萜 黄酮 糖尿病 高血脂 |
| 收稿时间： | 2022/12/8 0:00:00 |
Research progress on chemical constituents and anti-metabolic disease pharmacological effects of Cyclocarya paliurus |
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| XU Ruo-chen,ZHANG Peng,XIANG Ming.Research progress on chemical constituents and anti-metabolic disease pharmacological effects of Cyclocarya paliurus[J].Chinese Traditional and Herbal Drugs,2023,54(9):2962-2977. |
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| Authors: | XU Ruo-chen ZHANG Peng XIANG Ming |
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| Institution: | Department of Biopharmacology, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, China;Department of Traditional Chinese Medicine and Natural Medicine, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, China;Hubei Key Laboratory of Natural Medical Chemistry and Resource Evaluation, Wuhan 430000, China; Department of Biopharmacology, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, China;Hubei Key Laboratory of Natural Medical Chemistry and Resource Evaluation, Wuhan 430000, China |
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| Abstract: | Qingqianliu (Cyclocarya paliurus) belongs to the genus Cyclocarya in Juglandaceae family, with the function of engendering liquid and quenching thirst, lowering blood pressure and strengthening heart. Metabolic diseases are recognized as a group of diseases characterized by metabolic disorder, including diabetes, hyperlipidemia, hypertension, high uric acid and liver disease, and are the main cause of sub-health conditions worldwide. Cyclocarya paliurus is rich in active ingradients such as triterpenes, flavonoids and polysaccharides, and has hypoglycemia, hypolipidemic, antihypertensive, anti-uric acid, liver protection and other effects. This article reviews the chemical composition and pharmacological effects of Cyclocarya paliurus against metabolic diseases, in order to provide reference for the subsequent research, development and utilization of this resource. |
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| Keywords: | Cyclocarya paliurus (Batal ) Ijinskaja triterpenes flavonoids diabetes hyperlipidemia |
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