Risk of Total Knee and Hip Arthroplasty in Patients With Rheumatoid Arthritis: A 12-Year Retrospective Cohort Study of 65,898 Patients |
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| Affiliation: | 1. Department of Health Services Administration, China Medical University, Taichung, Taiwan;2. Department of Public Health, China Medical University, Taichung, Taiwan;3. Department of Orthopedics, Cishan Hospital, Ministry of Health and Welfare, Kaohsiung, Taiwan;4. Department of Center for General Education, National United University, Miaoli, Taiwan;5. Department of Medicine, School of Medicine, Chung Shan Medical University, Taichung, Taiwan;6. Department of Human Resource, Chia Yi Hospital, Ministry of Health and Welfare, Chia Yi, Taiwan;7. Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan;8. College of Medicine, China Medical University, Taichung, Taiwan;9. Department of Rheumatology, BenQ Medical Center, The Affiliated BenQ Hospital of Nanjing Medical University, Nanjing, China;10. Department of Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan;11. Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan;12. Graduate Institute of Integrated Medicine, China Medical University, Taichung, Taiwan;1. Département Universitaire de Chirurgie Orthopédique et Traumatologique, Univ. Lille, CHU Lille, Lille, France;2. Service d’orthopédie C, Hôpital Roger Salengro, Centre Hospitalier Régional Universitaire de Lille, Lille, France;3. Clinique d''Arcachon, La Teste de Buch, France;4. Clinique Médipole-Garonne, Toulouse, France;5. Clinique la Louviere, Rue de la Louvière, Lille, France;6. ReSurg SA, Nyon, Switzerland;1. Department of Orthopaedic Surgery, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea;2. Department of Orthopaedic Surgery, Eunpyeong St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea;1. Department of Orthopedic Surgery, Ascension Providence Rochester, Rochester, MI;2. Department of Orthopedic Surgery, Rush University Medical Center, Chicago, IL;3. University of Tennessee - Campbell Clinic Orthopaedics, Memphis, TN;1. Department of Orthopedics and Traumatology, Metin Sabancı Baltalimanı Bone Diseases Training and Research Hospital, İstanbul, Turkey;2. Deparment of Orthopedics and Traumatology, Vital Hospital, İstanbul, Turkey;3. Department of Orthopedics and Traumatology, Health Sciences University Turkey, Metin Sabancı Baltalimanı Bone Diseases Training and Research Center, İstanbul, Turkey;1. Orthopaedic Surgery Department, Hôpital Saint Antoine, Assistance Publique, Hôpitaux de Paris, Paris, France;2. Groupe Maussins, Clinique de l’épaule, Clinique Maussins Nollet, Groupe Ramsay Générale de Santé, Paris, France;5. Artro Institute, Lyon, France;6. Department of Orthopaedic Surgery, Clinique d''Argonay, Pringy, Annecy, France;7. Centre de Chirurgie Orthopédique du Beaujolais, Arnas, France;1. Hôpital Privé Jean Mermoz, Centre Orthopédique Santy, Ramsay Santé, Lyon, France;2. Artro Institute, Lyon, France;3. Department of Orthopaedic Surgery and Sports Medicine, Centre Hospitalier Lyon-Sud, Pierre-Bénite, France;4. ReSurg SA, Nyon, Switzerland |
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| Abstract: | BackgroundRheumatoid arthritis (RA) is an inflammatory disease that causes the destruction of soft tissues and cartilage around joints. Owing to the widespread use of potent disease-modifying antirheumatic drugs, the need for total knee and hip arthroplasties (TKA and THA) has been reduced in patients with RA. However, the current association between RA and either THA or TKA has not been demonstrated in large-scale epidemiological studies.MethodsWe conducted a large-scale retrospective cohort study of patients diagnosed with RA during a 12-year period (2000-2012) in Taiwan. We recruited 32,949 patients with RA and 32,949 individually propensity score-matched non-RA controls.ResultsAfter adjusting for confounding factors, we found that the risk of THA or TKA was 4.02 times higher in patients with RA than in those without RA (95% confidence interval [CI], 3.77-4.52). The risk of THA or TKA was highest in patients with RA younger than 40 years (adjusted hazard ratio, 43.18; 95% CI, 16.01-116.47). Compared with non-RA patients, patients with RA were 4.82 times more likely to undergo THA (95% CI, 3.84-6.04), 3.85 times more likely to undergo TKA (95% CI, 3.48-4.25), and 19.06 times more likely to undergo both THA and TKA (95% CI, 8.90-40.80).ConclusionThese findings document a 4.02-fold greater long-term risk of undergoing THA or TKA in RA patients relative to non-RA patients in Taiwan. |
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| Keywords: | rheumatoid arthritis total knee arthroplasty total hip arthroplasty population-based cohort study risk big data |
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