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Postnatal maternal deprivation and pubertal stress have additive effects on dopamine D2 receptor and CaMKII beta expression in the striatum |
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| Authors: | Gabriela Novak,Theresa Fan,Brian F. O&rsquo Dowd,Susan R. George |
| Affiliation: | 1. Centre for Addiction and Mental Health, Toronto, Ontario, Canada;2. Department of Pharmacology, University of Toronto, Toronto, Ontario, Canada;3. Department of Medicine, University of Toronto, Toronto, Ontario, Canada |
| Abstract: | The goal of this study was to determine whether two stressors commonly used to model aspects of neuropsychiatric disease in rats have an additive effect on striatal dopamine type 2 receptor (D2R) expression, a key player in the etiology of neuropsychiatric disease. |
| Keywords: | Maternal deprivation Immobilization stress Schizophrenia Dopamine Dopamine D2 receptor D2R CaMKII Striatum Gene expression Postnatal Puberty Animal model Two-hit hypothesis Corticosterone Neurodevelopment |
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