事件相关电位及脑电地形图对睡眠呼吸暂停综合征患者认知功能的评价

目的 :探索睡眠呼吸暂停综合征 (SAS)患者认知功能和临床疗效的评价方法。方法 :利用事件相关电位 (ERP)、脑电地形图 (BEAM)检测和简易智力状态试验 (MMSE)观察SAS患者 (分症状轻的SAS—A和症状重的SAS—B两个亚组 )经鼻持续气道内压通气 (CPAP)治疗前后认知功能的变化 ,并与对照组进行比较。结果 :与对照组比较 ,P30 0潜伏期明显延长 (P <0 0 5 ) ,波辐降低 (P <0 0 5 ) ;SAS—B组MMSE测试得分较低 ,SAS—A组近于正常 ,SAS—A组与SAS—B组之间BEAM总异常率及部分异常频带分布无显著差异 (P >0 0 5 )。结论 :ERP—P30 0、BEAM结合MMSE是观察SAS患者认知功能的有效方法

Evaluation of cognitive function in patients with sleep apnea syndrome by ERP and BEAM

Objective:To explore the means of evaluating the cognitive function and clinical therapeutic effect of patients with sleep apnea syndrome(SAS). Methods:ERP, BEAM and MMSE were used to observe the changes of cognitive function in patients with SAS(devided into SAS-A group with mild symptoms and SAS-B group with severe symptoms),before and after CPAP.The results were compared with the control group.Result:The latency of P300 increased and the amplitude of P300 decreased significantly as compared with the control.The marks of MMSE test decreased in SAS-B group and were nearly normal in SAS-A group.No significant difference of the total abnormality rate and partial abnormal band distribution of BEAM was noted between SAS-A and SAS-B.Conclusion:Combination of ERP-P300,BEAM and MMSE might be an effective method to observe the cognitive function of patients with SAS.