Structural comparisons of meptazinol with opioid analgesics |
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Authors: | Li Wei Hao Jing-lai Tang Yun Chen Yan Qiu Zhui-bai |
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Affiliation: | Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai 200032, China. |
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Abstract: | AIM: To investigate the mechanism of action of a potent analgesic, (+/-)-meptazinol. METHODS: The structures of meptazinol enantiomers were compared with opioid pharmacophore and tramadol. RESULTS: Neither enantiomer of meptazinol fitted any patterns among the opioid pharmacophore and tramadol, although they did share some structural and pharmacological similarities. However, the structure superpositions implied that both enantiomers of meptazinol might share some similar analgesic mechanisms with typical opiate analgesics. CONCLUSION: Meptazinol should have a different mechanism of action to known analgesics, which would be helpful in further investigations of meptazinol in the search for non-addictive analgesics. |
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