| 天星定痫胶囊快速质量控制方法研究 |
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| 引用本文： | 董占军,韩桂茹. 天星定痫胶囊快速质量控制方法研究[J]. 中国药房, 2008, 19(27): 2116-2118 |
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| 作者姓名： | 董占军 韩桂茹 |
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| 作者单位： | 1. 河北省人民医院药学部,石家庄市,050051
2. 河北省药品检验所,石家庄市,050011 |
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| 摘 要： | 目的:建立简便、快捷的天星定痫胶囊质量控制方法。方法:采用薄层色谱(TLC)法鉴别地龙、冰片、丹参、钩藤、琥珀、人工牛黄、甘草、人参皂苷Rg1和白芍;采用高效液相色谱法测定丹参酚酸B的含量。结果:TLC鉴别斑点清晰,分离度好,阴性无干扰。丹参酚酸B的进样量在0.06144～1.92μg范围内与峰面积积分值呈良好的线性关系(r=0.9998);平均回收率为99.33%,RSD=1.76%(n=9)。结论:本方法可用于快速控制天星定痫胶囊的质量。
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| 关 键 词： | 天星定痫胶囊 薄层色谱法 高效液相色谱法 质量控制 |
Quality Control of Tianxing Dingxian Capsules |
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| DONG Zhan-jun,HAN Gui-ru. Quality Control of Tianxing Dingxian Capsules[J]. China Pharmacy, 2008, 19(27): 2116-2118 |
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| Authors: | DONG Zhan-jun HAN Gui-ru |
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| Affiliation: | DONG Zhan-jun,HAN Gui-ru (1Dept. of Pharmacy, Hebei Provincial People＇s Hospital,Shijiazhuang 050051,China;2Hebei Provincial Institute for Drug Control,Shijiazhuang 050011,China) |
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| Abstract: | OBJECTIVE： To establish a simple and rapid method for the quality control of Tianxing dingxian capsules. METHODS： Pheretima, Borneolum Syntheticum, Salvia rniltiorrhiza, Ramulus Uncariae Curn Uncis, Succinum, Calculus Bovis Artifactius, Radix et Rhizoma Glycyrrhizae, Ginsenoside Rg1 and Paeonia lactiflora were identified by TLC. The content of Salvianolic acid B in the Tianxing dingxian capsules was determined by HPLC.RESULTS： The TLC spots were clear, well- seperated yet without interference from negative Samples.The linear range of Salvianolic acid B was 0.061 44-1.92μg（r = 0.999 8）, and its average recovery was 99.33% （RSD = 1.76%, n = 9） .CONCLUSION：The method can be used for the rapid quality control of Tianxing dingxian capsules. |
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| Keywords: | Tianxing dingxian capsules TLC HPLC Quality control |
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