血清尿酸水平及性别差异与血压关系的研究

目的观察血清尿酸水平与血压的关系,探讨性别对二者关系的影响。方法选择体检人群979例进行问卷、人体测量,测定血清尿酸浓度,并按四分位间距分为Q1~Q4组。结果①总人群及女性人群中,尿酸与收缩压、平均动脉压显著相关(P<0.05),与舒张压、脉压差无关(P>0.05);男性人群中,尿酸与各血压值均无关(P>0.05);②Logistic回归显示,女性Q4组高血压患病较Q1组增高58.5%(P>0.05),总人群Q4组高血压患病较Q1组增高56.3%(P>0.05),在男性组差异无统计学意义。结论血清尿酸水平与收缩压、平均动脉压及高血压患病率相关,且具有性别差异。

Relationship between serum uric acid level and blood pressure and gender differences

Objective To investigate the relationship between uric acid and blood pressure in a physical examination population and explore the genderA1.related differences.Methods We randomly selected 979 subjects aged 30-75 years in physical examination centre of Changzhou No.1 People′s Hospital.A standardized questionnaire was used to collect information on general information.Blood pressure,height,weight,waist,hip,heart rate,concentration of serum lipid,glucose and uric acid were measured.Subjects were divided into 4 groups according to their interquartile range of uric acid levels in general population,male group and female group: group Q1(general population: uric acid <228.3 μmol/L;male group: uric acid <280.0 μmol/L;female group: uric acid <204.1 μmol/L);group Q2:(general population: 228.3 μmol/L ≤ uric acid < 284.2 μmol/L;male group: 280.0 μmol/L ≤ uric acid < 331.9 μmol/L;female group: 204.1 μmol/L ≤ uric acid <246.6 μmol/L);group Q3:(general group: 284.2 μmol/L ≤ uric acid <348.7 μmol/L;male group: 331.9 μmol/L ≤ uric acid <383.3μmol/L;femal group: 246.6 μmol/L ≤uric acid < 294.9 μmol/L);group Q4:(general group: uric acid ≤ 348.7 μmol/L;male group: uric acid ≤ 383.3 μmol/L;female group: uric acid ≤ 294.9 μmol/L).Results ① After being adjusted for regular risk factors,systolic blood pressure(for general population: P=0.024;for female group: P=0.023) and mean arterial pressure(for general population: P=0.0018;for female group: P=0.025) were associated with serum uric acid levels,while diastolic blood pressure and pulse pressure were not related to serum uric acid levels both in general population and female group(P>0.05).In male group,none of the blood pressure indices was related to uric acid levels(P>0.05).② Logistic regression analysis revealed that the prevalence of hypertension in Q4 group increased by 58.5% compared with that in Q1 in the female group(95% confidence interval: 12.9%-22.4%),while in the male group,there was no statistical significance.In the total population,after further adjustment for gender,the prevalence of hypertension in Q4 group increased by 56.3% compared with that in Q1 group(95% confidence interval: 25.6%-94.5%).Conclusion Serum uric acid level was associated with systolic blood pressure,mean arterial pressure and prevalence of hypertension which was dependent on gender differences.