血清HGVRNA阳性病毒性肝炎94例研究

目的分析血清HGVRNA阳性病毒性肝炎的临床特点。方法全部病例入院后即检测血清AB，C，D，E型肝炎病毒标志及肝功能试验，抗-HGV采用ELISA法，HGVRNA采用RT-PCR法，均由302医院免疫室统一检测．结果在94例血清HGVRNA阳性患者中，单纯HGV感染（单纯感染组）18例，HGV合并其他肝炎病毒感染（合并感染组）76例，单纯感染组中以急性肝炎为主（61．1％），合并感染组以HBV＋HGV感染最多，占引例（5．3％）．51例中，以慢性肝炎（41．2％）及肝硬变（37．2％）为主，单纯HGV感染临床可表现为急、慢性肝炎及重型肝炎，其中，急性肝炎临床特点为：消化道症状较轻：半数以上有轻-中度黄疸，也可有重度黄疸者；ALT轻度增高；全部病例恢复顺利，合并感染组病情恢复也较顺利．11例重型肝炎，生存率45．4％．HGV与HBV合并感染者中，住院期间，HBsAg阴转率24．0％，HBeAg阴转率62．5％，HBVDNA阴转率55．6％结论单纯HGV感染以急性肝炎为主，亦可见于慢性肝炎及重型肝炎，合并感染级以慢性肝炎及肝硬变为主，并分析各自临床特点HGV与HBV合并感染时，对HBV可能有抑制作用.

Clinical characters and significance for 94 viral hepatitis patients with serum HGVRNA

AIM To analyze the clinical characters and significance of viral hepatitis in 94 petients infected with HGV.METHODS After admission 94 petients were tested on anti-HAV, HBV-marker, anti-HCV, anti-HDV, anti-HEV and anti-HGV by ELISA method, HBVDNA-HGVRNA and HCVRNA were detheted by PCR and RT-PCR method.Serum ALT, Bil, total protein lerel and albumin level were also detected.RESULTS Of all the 94 Patients who were HGVRNA positive in serum, 18 patients were infected with HGV only, 76 petients were coinfected with more than one hepatitis viruses. In the group inboed with HGV, most patients had the symptoms of acute hepetitis (61. 1% ). In the group co-infected with hepatitis viruses, most petients were co-infected with HBV and HGV who made up for 54.3% (51 cases) of all co-inforted petients and were composed by chrooic hepetitis and cirrhosis (41. 1% and 37.2% respetively). In acute hepatitis the patients only had mild nausea and were accompanied by mild-moderate jaundice and ALT level, and all petients recoered smoothly. In co-infected group of 11 petients, the survival rate were 45.5%. In patients co-infedted with HBV and HGV, the clearance rate of HBsAg were 24.0%; HBeAg were 62. 5%; HBVDNA were 55. 6%.CONCLSION In patients infected with HGV, besides some chronic and a few fulminant hepatitis, most were acute hepatitis. In co-infected group, most patients were chrooic hepatitis and cirrhosis, When petients were coinfected with HGV and HBV, HGV may inhibit HBV replication and be helpful in clearance of HBV.