凋亡相关基因bcl—2和bax在结肠肿瘤的表达及意义

用免疫组织化学方法观察３９例结肠癌凋亡相关基因ｂｃｌ－２和ｂａｘ的表达，以１７例结肠腺瘤作为对照。结果显示：ｖｃｌ－２和ｂａｘ在结肠癌和结肠腺瘤的表达率分别为３３．３３％，１．０３％，３０．７７％和４１．１８％，２３．５３％，４１．１８％，结肠癌和结肠腺瘤中ｂｃｌ－２和ｂａｘ表达率比较均无显著性差异。

Expressions and Significance of Apoptosis Related Gene bcl-2 and bax in Colorectal Carcinoma

Expressions of apoptosis related gene bcl-2 and bax in 39 cases of colorectal carcinoma and 17 cases of colorectal adenomas as contrast were detected by Streptavidin-biotin-peroxidase complex (SABC) method. The results revealed that bcl-2 immunoreactivity (strongly and weakly positive) and bax im-munoreactivity in colorectal carcinomas and adenomas respectively were 33. 33%, 41. 03% , 30. 77% and41. 18% ,23. 53% ,41. 18% ,there were no obvious difference between expressions of bcl-2 and bax in colorectal carcinomas and adenomas (P>0. 05). Expressions of bcl-2 in well or moderately differentiated colorectal carcinomas were significantly different from poorly differentiated colorectal carcinomas (P<0. 05) ,but there were no obvious difference in expression of bax. Expressions of bcl-2 and bax in coiorectal carcinoma were correlated positively (r = 0. 67,P<0. 01). The results suggested expressions of bcl-2 and bax were related to differentiation in coiorectal tumors,and expressions of bcl-2 and bax in coiorectal carcinomas had no correlation with Dukes clinic stages of coiorectal carcinomas.