| 鼻外NK/T细胞淋巴瘤21例临床特征及预后分析 |
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| 引用本文： | 归薇,关涛,赵瑾,马莉,王晶荣,韩维娥,杨斌,白敏,苏丽萍. 鼻外NK/T细胞淋巴瘤21例临床特征及预后分析[J]. 白血病．淋巴瘤, 2014, 23(8): 480-483 |
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| 作者姓名： | 归薇 关涛 赵瑾 马莉 王晶荣 韩维娥 杨斌 白敏 苏丽萍 |
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| 作者单位： | 1. 山西省肿瘤医院血液科, 太原,030013
2. 山西省肿瘤医院血液实验室, 太原,030013 |
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| 摘 要： | 目的 探讨鼻外NK/T细胞淋巴瘤的临床特征与预后.方法 对21例鼻外NK/T细胞淋巴瘤的病例资料进行回顾性分析,并复习相关文献.结果 患者以晚期、有B症状、体能状态（ECOG评分）2～4分、国际预后指数（IPI）3～5分和乳酸脱氢酶（LDH）升高者为多,除1例放弃治疗外,20例患者中,完全缓解5例,部分缓解1例,总生存率为30.0％.早期患者疗效较好,2例晚期合并噬血细胞综合征和弥散性血管内凝血的患者预后最差.结论 鼻外NK/T细胞淋巴瘤患者的预后较差,临床分期、ECOG、IPI和LDH是影响预后的主要因素.
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| 关 键 词： | 鼻外NK T细胞淋巴瘤 临床特征 药物疗法 联合 预后 |
Clinical features and prognostic analysis of 21 patients with extranasal NK/T cell lymphoma |
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| Affiliation: | Gui Wei Guan Tao, Zhao Jin, Ma Li, Wang Jinrong, Han Weie, Yang Bin, Bai Min, Su Liping. (Department of Hematology, Shanxi Cancer Hospital, Taiyuan 030013, China) |
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| Abstract: | Objective To study the clinical features and prognosis of extranasal NK/T cell lymphoma.Methods The clinical data of 21 patients with extranasal NK/T cell lymphoma were analyzed retrospectively.The related literatures were reviewed.Results Majority of patients presented advanced stage,B symptoms,ECOG 2-4 scores,IPI 3-5 scores and high level of LDH.One case gave up treatment.Among 20 cases,there were 5 cases CR and 1 case PR,the overall survival was 30.0 %.The therapeutic effect of early stage cases was better.Two advanced stage cases with complicated hemophagocytic syndrome and DIC presented worst outcome.Conclusion The prognosis of extranasal NK/T cell lymphoma is poor,clinical stage,ECOG score,IPI score and LDH level are principle factors that affect prognosis. |
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| Keywords: | Extranasal NK/T cell lymphoma Clinical features Drug therapy,combination Prognosis |
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