Vascular endothelial growth factor:an essential neurotrophic factor for motoneurons?

正Vascular endothelial growth factor(VEGF),an angiogenic factor with neuroprotective effects:The VEGF was initially characterized by its vasculogenic and angiogenic activities and its capacity to promote vascular permeability(Yancopoulos et al.,2000).VEGF is also known as VEGF-A and is the prototype member of a related group of five trophic factors,VEGF-B,VEGF-C,VEGF-D and placental growth factor(Pl GF;Lange et al.,2016).Interestingly,VEGF-B shares a high degree of homology